Guillain-Barre syndrome is an autoimmune disorder with the most common clinical presentation of neuromuscular paralysis. Here we have reported a rare case of GBS in a 60-year-old male patient admitted to the male medicine ward with a chief complaint of weakness in B/L upper limb and B/L lower limb from 5 -7 days. Laboratory investigation of biochemistry analysis shows CSF protein (161mg/dl), neutrophils (91%), and S.Urea (44.0 mg/dl). Radiological investigation CT scan of the brain shows atrophic changes and MRI cervical spine -shows cervical spondylosis with compression myelopathic changes at C4, and C5 level and multilevel disc herniation and bulges. Nerve conduction studies of all four limbs were also performed by sampling from the median, ulnar, peroneal, tibial, and sural nerves. It shows B/L Upper and Lower limb (sensor + motor) demyelinating polyneuropathy. more prevalent in the upper limb than in the lower limbs. After being admitted, the patient received treatment that included antibiotics, analgesics, muscle relaxants, multivitamins, and other supportive measures. Intravenous immunoglobulin infusion was started due to the patient's symptoms steadily getting worse, and soon after that, things started to get better for the patient.
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