Transferosomal gel for transdermal delivery of insulin: Formulation development and ex vivo permeation study

V. Padma Prashanthini; Shanmugapriyan Sivaraman; Parimala Kathirvelu; Jaikumar Shanmugasundaram; Viswanathan Subramanian; Shakthi Sharanya Ramesh; E. Karthikeyan; Binoy Varghese Cheriyan

doi:10.1016/j.ipha.2023.07.001

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Intelligent Pharmacy ›› 2023, Vol. 1 ›› Issue (4) : 212-216. DOI: 10.1016/j.ipha.2023.07.001

Research Article

Transferosomal gel for transdermal delivery of insulin: Formulation development and ex vivo permeation study

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Abstract

The study was to develop a transdermal formulation of insulin, determine its pharmaceutical characteristics, and finally test its efficacy. In the current study - Transfersomes were selected as the carrier system for insulin. The transfersomes were produced by the hand-shaking method using soy lecithin phospholipid and sodium deoxycholate as the objective of the surfactant. The prepared transfersomes were subjected to characterization with optical microscopy and scanning electron microscope to estimate the shape and size of transfersomes respectively. In addition, the physical and drug-excipient interaction studies were carried out and the transfersomes were also studied for the insulin entrapment efficiency.

Results of the study showed the shape of the transfersomes was well defined and spherical. The mean size of transfersomes was estimated to be 130 nm The transfersomes were found to be stable over a period of four weeks. The insulin entrapment efficiency of the transfersomes was estimated to be 87.3%. The ex-vivo skin permeation study employing goat ear skin with the transfersomes hydrogel revealed that there was a slow and sustained release of insulin till 180 min. From the above study, it may be concluded that transfersomes are suitable carriers of insulin across biological membranes.

Keywords

Insulin / Transferosomes / Transdermal patches / Ex-vivo study / Hand-shaking method / Goat ear skin

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V. Padma Prashanthini, Shanmugapriyan Sivaraman, Parimala Kathirvelu, Jaikumar Shanmugasundaram, Viswanathan Subramanian, Shakthi Sharanya Ramesh, E. Karthikeyan, Binoy Varghese Cheriyan. Transferosomal gel for transdermal delivery of insulin: Formulation development and ex vivo permeation study. Intelligent Pharmacy, 2023, 1(4): 212‒216 https://doi.org/10.1016/j.ipha.2023.07.001

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2023 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).