Editing of BoMLO12 confers broad-spectrum disease resistance and enhanced yield in Brassica oleracea

Yulun Zhang , Guanzhong Huo , Limei Yang , Yangyong Zhang , Mu Zhuang , Yong Wang , Jialei Ji , Xuehui Yao , Honghao Lv

Horticulture Research ›› 2026, Vol. 13 ›› Issue (4) : 9

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Horticulture Research ›› 2026, Vol. 13 ›› Issue (4) :9 DOI: 10.1093/hr/uhag009
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Editing of BoMLO12 confers broad-spectrum disease resistance and enhanced yield in Brassica oleracea
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Yulun Zhang, Guanzhong Huo, Limei Yang, Yangyong Zhang, Mu Zhuang, Yong Wang, Jialei Ji, Xuehui Yao, Honghao Lv. Editing of BoMLO12 confers broad-spectrum disease resistance and enhanced yield in Brassica oleracea. Horticulture Research, 2026, 13 (4) : 9 DOI:10.1093/hr/uhag009

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Acknowledgements

This work was supported by grants from the National Key R&D Program of China (2023YFD1201501), the Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences (CAAS-ASTIP-IVFCAAS), and the China Agriculture Research System of MOF and MARA (CARS-23).

Author contributions

H.L. conceived and designed the experiments. Y.Z. and G.H. performed the experiments and data analysis. Y.Z. and G.H. wrote the manuscript. L.Y., Y.Y.Z., M.Z., Y.W, J.J., and X.Y. provided valuable advice on the manuscript. H.L. revised the manuscript. All authors contributed to the article and approved the submitted version.

Data availability

The authors confirm that the data supporting the findings of this study are available within the article.

Conflicts of interest statement

The authors declare no conflicts of interest.

References

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Zhang X, Jia Q, Jia X, et al. Brassica vegetables-an undervalued nutritional goldmine . Hortic Res. 2024; 12: uhae302

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Gao C . Genome engineering for crop improvement and future agriculture. Cell. 2021; 184: 1621-35

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Zhang YL, Liu JH, Li YJ, et al. Generation of novel bpm6 and dmr6 mutants with broad-spectrum resistance using a modified CRISPR/Cas9 system in Brassica oleracea . J Integr Plant Biol. 2025; 67: 1214-6

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Li S, Lin D, Zhang Y, et al. Genome-edited powdery mildew resistance in wheat without growth penalties. Nature. 2022; 602: 455-60

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Qiu D, Xiao J, Ding X, et al. OsWRKY13 mediates rice disease resistance by regulating defense-related genes in salicylate- and jasmonate-dependent signaling. Mol Plant-Microbe Interact. 2007; 20: 492-9

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