Haplotype-resolved genome assembly of Corydalis yanhusuo, a traditional Chinese medicine with unusual telomere motif

Dingqiao Xu , Ziqi Ye , Yongji Huang , Kejin Zhu , Hongbo Xu , Jingao Yu , Yimeng Feng , Xinyue Zhao , Long Wang , Hao Xu , Qien Li , Minjian Qin , Yuping Tang , Xingtan Zhang , Yucheng Zhao

Horticulture Research ›› 2024, Vol. 11 ›› Issue (2) : 296

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Horticulture Research ›› 2024, Vol. 11 ›› Issue (2) :296 DOI: 10.1093/hr/uhad296
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Haplotype-resolved genome assembly of Corydalis yanhusuo, a traditional Chinese medicine with unusual telomere motif
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Dingqiao Xu, Ziqi Ye, Yongji Huang, Kejin Zhu, Hongbo Xu, Jingao Yu, Yimeng Feng, Xinyue Zhao, Long Wang, Hao Xu, Qien Li, Minjian Qin, Yuping Tang, Xingtan Zhang, Yucheng Zhao. Haplotype-resolved genome assembly of Corydalis yanhusuo, a traditional Chinese medicine with unusual telomere motif. Horticulture Research, 2024, 11 (2) : 296 DOI:10.1093/hr/uhad296

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Author contributions

Y.C.Z., X.T.Z., and Y.P.T. conceived and designed the research. D.Q.X., Z.Q.Y., H.B.X., J.G.Y., K.J.Z., and L.W. collected the samples. D.Q.X., Z.Q.Y., and Y.J.H. performed the genome assembly, experimental and data analysis. Y.M.F., X.Y.Z., H.X., L.Q.N., and M.J.Q. also performed the experimental and data analysis. D.Q.X. wrote the manuscript. Y.C.Z., X.T.Z., Z.Q.Y., and Y.J.H. revised the manuscript.

Acknowledgements

This project was funded by the open foundation of Shaanxi University of Chinese Medicine State Key Laboratory of R&D of Characteristic Qin Medicine Resources (SUCM-QM202202) and the key project at central government level: the Ability Establishment of Sustainable Use for Valuable Chinese Medicine Resources (2060302). It was also supported by the Fund of Traditional Chinese Medicine Institute of Anhui Dabie Mountain (TCMADM-2023-18), the Double First-Class University Project (CPU2022QZ27), and a grant from the Key Research and Development Program of Shaanxi (2022SF-543).

Data availability

The data that support the findings of this study have been deposited in the CNGB Sequence Archive (CNSA) of the China National GeneBank DataBase (CNGBdb) with accession number CNP0004356.

Conflict of interest

The authors declare no conflict of interest.

References

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Xia GY, Fang DJ, Wang LY. et al. 13,13a-Seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity. Phytochemistry. 2022; 194 :113023

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Bu J, Zhang X, Li Q. et al. Catalytic promiscuity of O-methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids. Hortic Res. 2022; 9 :uhac152

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Xu Z, Li Z, Ren F. et al. The genome of Corydalis reveals the evolution of benzylisoquinoline alkaloid biosynthesis in Ranunculales. Plant J. 2022; 111 :217-30

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