%A Yan-Hui Liu, Ying-Bing Chen, Wei Mao, Lin Hu, Lin-Hong Deng, Hou-Qiang Xu %T Dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle %0 Journal Article %D 2014 %J Front. Phys. %J Frontiers of Physics %@ 2095-0462 %R 10.1007/s11467-014-0412-6 %P 519-522 %V 9 %N 4 %U {https://journal.hep.com.cn/fop/EN/10.1007/s11467-014-0412-6 %8 2014-08-26 %X

Recent experiments have pointed out that cellular uptake is strongly dependent on the physical dimensions of endocytosed nanoparticles and the optimal radius of endocytosed virus-like particle coated by transferrin is around 50 nm. As the same time, the dimensions of receptor-ligand complex have strong effects on the size-dependent exclusion of proteins in cell environments. Inspired by these experimental results, a continuum elastic model is constructed to resolve the relationship between the dimensions of receptor-ligand complex and the optimal radius of endocytosed virus-like particle. These results demonstrate that the optimal radius of endocytosed virus-like particle depends on the dimensions of receptor-ligand complex and the dimension of receptor-ligand complex reduces the depletion zone.