%A Fen LAN, Shengdao XIONG, Weining XIONG, Guopeng XU, Xiaoxia LU %T Expression of Syk in non-small cell lung cancer and its relationship with clinicopathological parameters %0 Journal Article %D 2009 %J Front. Med. %J Frontiers of Medicine %@ 2095-0217 %R 10.1007/s11684-009-0009-6 %P 41-44 %V 3 %N 1 %U {https://journal.hep.com.cn/fmd/EN/10.1007/s11684-009-0009-6 %8 2009-03-05 %X
This study aims to research the expression of spleen tyrosine kinase (Syk) in non-small cell lung cancer (NSCLC) and the relationship between Syk and clinicopathologic factors and p53. Immunohistochemistry was applied to detect the expression of Syk and p53 protein in 39 cases of NSCLC (23 cases of lung squamous cell cancer, 16 cases of lung adenocarcinoma) and tumor-surrounding normal lung tissues. The positive rate of Syk was 46.15% (18/39) and 100% (39/39) in NSCLC and tumor-surrounding normal lung tissues, respectively. The expression level of Syk in NSCLC was significantly lower than that in tumor-surrounding normal lung tissues (