%A Xuefu Wang, Zhigang Tian %T γδ T cells in liver diseases %0 Journal Article %D 2018 %J Front. Med. %J Frontiers of Medicine %@ 2095-0217 %R 10.1007/s11684-017-0584-x %P 262-268 %V 12 %N 3 %U {https://journal.hep.com.cn/fmd/EN/10.1007/s11684-017-0584-x %8 2018-05-04 %X

γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit liver-specific features. Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholic fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regeneration. In this study, we review the properties of hepatic γδ T cells and summarize the roles of γδ T cells in liver diseases. We believe that determining the properties and functions of γδ T cells in liver diseases enhances our understanding of the pathogenesis of liver diseases and is useful for the design of novel γδ T cell-based therapeutic regimens for liver diseases.