Frontiers of Medicine >

2010 , Vol. 4 >Issue 3: 303 - 307

DOI: https://doi.org/10.1007/s11684-010-0090-x

RESEARCH ARTICLE

Difference between 2 h and 3 h 75 g glucose tolerance test in the diagnosis of gestational diabetes mellitus (GDM): Results from a national survey on prevalence of GDM

  • Xue-Lian GAO 1 ,
  • Yu-Mei WEI 1 ,
  • Hui-Xia YANG , 1 ,
  • Xian-Ming XU 2 ,
  • Ling FAN 3 ,
  • Jing HE 4 ,
  • Ning LIU 5 ,
  • San-Cun ZHAO 6 ,
  • Ya-Li HU 7 ,
  • Zi YANG 8 ,
  • Yun-Ping ZHANG 9 ,
  • Xing-Hui LIU 10 ,
  • Xu CHEN 11 ,
  • Jian-Ping ZHANG 12 ,
  • Wen-Li GOU 13 ,
  • Mei XIAO 14 ,
  • Hai-Rong WU 15 ,
  • Mei-Hua ZHANG 16
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  • 1. Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China
  • 2. Department of Obstetrics and Gynecology, First Affiliated People’s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
  • 3. Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
  • 4. Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
  • 5. Maternal and Child Health Care Hospital of Urumchi, Urumchi 830000, China
  • 6. Maternal and Child Health Care Hospital of Shanxi, Xi’an 710003, China
  • 7. Department of Obstetrics and Gynecology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
  • 8. Peking University Third Hospital, Beijing 100191, China
  • 9. Maternal and Child Health Care Hospital of Haidian District, Beijing 100080, China
  • 10. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • 11. Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin 300052, China
  • 12. Department of Obstetrics and Gynecology, the Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China
  • 13. Department of Obstetrics and Gynecology, the First Affiliated Hospital, Medical School of Xi’an Jiaotong University, Shanxi 710061, China
  • 14. Department of Obstetrics and Gynecology, Hubei Maternal & Child Health Hospital, Wuhan 430100, China
  • 15. The Central Hospital of Aviation Industry of China, Beijing 100012, China
  • 16. Taiyuan Maternal and Infant Health Care Hospital of Shanxi Province, Taiyuan 030012, China

Received date: 10 May 2010

Accepted date: 16 May 2010

Published date: 05 Sep 2010

Copyright

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg
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Abstract

The possibility of the 2 h oral glucose tolerance test (OGTT) as an alternative to the 3 h OGTT was investigated based on data from a national survey on pregnancy-associated diabetes. Data were retrieved from 4179 pregnant women who had OGTT performed after an abnormal 50 g glucose challenge test (GCT). All of the 4 glucose levels during their OGTT were collected and analyzed. According to American Diabetes Association (ADA) gestational diabetes mellitus (GDM) diagnostic criteria, among the 4179 pregnant women who required OGTT, 3429 (82.1%) were normal and 750 (17.9%) were diagnosed as GDM. If the 3rd h glucose levels were omitted from OGTT, 79 cases of GDM (10.5%) would be overlooked. No trend was shown where women with more risk factors were more likely to be overlooked if the 3rd h test was omitted (χ2 for trend= 0.038, P>0.05). No significant differences were found in the rate of cesarean section (CS), preterm births or macrosomia between the 79 cases and those with normal OGTT results and in the gestational weeks when OGTT was performed. It shows that in order to diagnose one woman with GDM, another 52 pregnant women would have an innocent 3rd h glucose test. Omission of the 3rd h glucose test in OGTT might be reasonable due to its convenience, better compliance and a small number of possibly miss-diagnosed cases, and their pregnancy outcomes have no significant difference from those of normal pregnant women.

Key words： diabetes; gestational; oral glucose tolerance test

Cite this article

Xue-Lian GAO , Yu-Mei WEI , Hui-Xia YANG , Xian-Ming XU , Ling FAN , Jing HE , Ning LIU , San-Cun ZHAO , Ya-Li HU , Zi YANG , Yun-Ping ZHANG , Xing-Hui LIU , Xu CHEN , Jian-Ping ZHANG , Wen-Li GOU , Mei XIAO , Hai-Rong WU , Mei-Hua ZHANG . Difference between 2 h and 3 h 75 g glucose tolerance test in the diagnosis of gestational diabetes mellitus (GDM): Results from a national survey on prevalence of GDM[J]. Frontiers of Medicine, 2010 , 4(3) : 303 -307 . DOI: 10.1007/s11684-010-0090-x

Acknowledgements

We have no conflict of interest with any companies or organizations.

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