Non small cell lung cancer with SMARCA4 deficiency harboring rare EGFR mutations exhibited significant tumor response when treated with afatinib: a case report

Abstract

SMARCA4-deficient non small cell lung cancer (SMARCA4-dNSCLC) has recently garnered increasing attention due to its high malignancy and poor prognosis. The literature suggests that in non small cell lung cancer (NSCLC), the loss of SMARCA4 frequently co-occurs with mutations in KRAS, KEAP1, and STK11 rather than in EGFR, ALK, and ROS1. Herein, we present the first documented case of SMARCA4-dNSCLC accompanied with rare mutations of EGFR exon 20 S768I and exon 18 G719X. The patient achieved partial response with afatinib for 17 months. Our case highlights the importance of EGFR mutations in the precision targeted treatment of SMARCA4-dNSCLC.

Keywords

SMARCA4-dNSCLC / rare EGFR mutations / targeted therapy / case report

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Acknowledgements

All authors contributed to the preparation, review, and approval of the manuscript and have consented to its submission for publication.

Electronic Supplementary Material

Supplementary material is available in the online version of this article at https://doi.org/10.1007/s11684-024-1118-y and is accessible for authorized users.

Compliance with ethics guidelines

Conflicts of Interest Xiaotong Qiu, Liangkun You, Chongwei Wang, and Jin Sheng declare no conflicts of interest.

Written informed consent was obtained from the individual for the publication of any potentially identifiable images or data included in this article.

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