Received date: 10 Dec 2010
Accepted date: 27 Jan 2011
Published date: 01 Aug 2011
Copyright
Alzheimer’s disease (AD) is the most common type of dementia that affects thinking, learning, memory and behavior of older people. Based on the previous studies, three pathogenic pathways are now commonly accepted as the culprits of this disease namely, amyloid-β pathway, tauopathology and cholinergic dysfunction. This review focuses on the current findings on the regulatory roles of G protein-coupled receptors (GPCRs) in the pathological progression of AD and discusses the potential of the GPCRs as novel therapeutic targets for AD.
Xiaosong LIU , Jian ZHAO . GPCR, a rider of Alzheimer’s disease[J]. Frontiers in Biology, 2011 , 6(4) : 282 -288 . DOI: 10.1007/s11515-011-1129-3
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