Metabolomics in Schizophrenia and Major Depressive Disorder
Received date: 16 Mar 2016
Accepted date: 15 Apr 2016
Published date: 05 Jul 2016
Copyright
Defining pathophenotype, a systems level consequence of a disease genotype, together with environmental and stochastic influences, is an arduous task in psychiatry. It is also an appealing goal, given growing need for appreciation of brain disorders biological complexity, aspiration for diagnostic tests development and ambition to identify novel drug targets. Here, we focus on the Schizophrenia and Major Depressive Disorder and highlight recent advances in metabolomics research. As a systems biology tool, metabolomics holds a promise to take part in elucidating interactions between genes and environment, in complex behavioral traits and psychopathology risk translational research.
Key words： Schizophrenia; Major Depressive Disorder; omics; metabolomics; systems biology
Iva Petrovchich , Alexandra Sosinsky , Anish Konde , Abigail Archibald , David Henderson , Mirjana Maletic-Savatic , Snezana Milanovic . Metabolomics in Schizophrenia and Major Depressive Disorder[J]. Frontiers in Biology, 2016 , 11(3) : 222 -231 . DOI: 10.1007/s11515-016-1400-8
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