Functional states of resident vascular stem cells and vascular remodeling
Received date: 24 Sep 2015
Accepted date: 30 Sep 2015
Published date: 30 Oct 2015
Copyright
Recent evidence indicates that different types of vascular stem cells (VSCs) reside within the mural layers of arteries and veins. The precise identities of these resident VSCs are still unclear; generally, postnatal vasculature contains multilineage stem cells and vascular cell lineage-specific progenitor/stem cells which may participate in both vascular repair and lesion formation. However, the underlying mechanism remains poorly understood. In this review, we summarize the potential molecular mechanisms, which may control the quiescence and activation of resident VSCs and highlight a notion that the differential states of resident VSCs are directly linked to vascular repair or lesion formation.
Key words： vascular stem cell; quiescence; activation; remodeling
Desiree F. Leach , Mitzi Nagarkatti , Prakash Nagarkatti , Taixing Cui . Functional states of resident vascular stem cells and vascular remodeling[J]. Frontiers in Biology, 2015 , 10(5) : 387 -397 . DOI: 10.1007/s11515-015-1375-x
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