%A Min SU, Lin WANG, Hua SUN, Jingkang WANG %T FBRM and PVM investigations of the double feed semi-batch crystallization of 6-aminopenicillanic acid %0 Journal Article %D 2009 %J Front. Chem. Sci. Eng. %J Frontiers of Chemical Science and Engineering %@ 2095-0179 %R 10.1007/s11705-009-0018-7 %P 282-288 %V 3 %N 3 %U {https://journal.hep.com.cn/fcse/EN/10.1007/s11705-009-0018-7 %8 2009-09-05 %X

6-Aminopenicillanic acid (6-APA) is a crucial pharmaceutical intermediate in the chemistry of semi-synthetic antibiotics. The focused beam reflectance measurement (FBRM) technology and particle vision measurement (PVM) technology were employed to the processes of online-monitoring of 6-APA crystallization behavior in a double-feeding semi-batch crystallizer. Experiments were carried out with four kinds of double-feeding policies and the results were compared with the traditional single-feeding. Records and analysis of FBRM indicated that the nucleation of double feeding policy was much higher than single policy, and chord length of 6-APA was almost determined and had little change after the nucleation peak. Ostwald ripening process had no significant effect on further growth of 6-APA crystal. PVM images showed that the crystal habit of 6-APA was continuously changed during the crystallization process. The development of (002) face in the final crystal for the five feeding policies were different.