Frontiers of Chemical Science and Engineering >

2013 , Vol. 7 >Issue 4: 490 - 495

DOI: https://doi.org/10.1007/s11705-013-1350-5

RESEARCH ARTICLE

Nucleation and growth mechanism of cefodizime sodium at different solvent compositions

  • Xinwei ZHANG , 1,2 ,
  • Shudong ZHANG 1 ,
  • Xiaodan SUN 1 ,
  • Zequn YIN 1 ,
  • Quanjie LIU 1 ,
  • Xiwen ZHANG 1 ,
  • Qiuxiang YIN 2
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  • 1. Fushun Research Institute of Petroleum and Petrochemicals, SINOPEC, Fushun 113001, China
  • 2. School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China

Received date: 06 Apr 2013

Accepted date: 02 Jun 2013

Published date: 05 Dec 2013

Copyright

2014 Higher Education Press and Springer-Verlag Berlin Heidelberg
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Abstract

The induction time of cefodizime sodium was measured in ethanol-water at different solvent compositions by the laser technology measurement. The results indicate that the solvent composition played an important role in the supersaturation and the nucleation process of cefodizime sodium solution. According to the modified classical nucleation theory, the nucleation and growth mechanism were identified. The correlation results show that heterogeneous nucleation dominated the nucleation process at lower supersaturation, where homogeneous nucleation is the most important mechanism at higher supersaturation. Based on the correlated results, the 2D mediated growth mechanism had the highest correlation coefficients (R2), so this mechanism was selected as the proper growth mechanism for cefodizime sodium.

Key words： cefodizime sodium; induction time; primary nucleation; growth mechanism

Cite this article

Xinwei ZHANG , Shudong ZHANG , Xiaodan SUN , Zequn YIN , Quanjie LIU , Xiwen ZHANG , Qiuxiang YIN . Nucleation and growth mechanism of cefodizime sodium at different solvent compositions[J]. Frontiers of Chemical Science and Engineering, 2013 , 7(4) : 490 -495 . DOI: 10.1007/s11705-013-1350-5

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