Thermodynamic study on dynamic water and organic vapor sorption on amorphous valnemulin hydrochloride

Abstract

The sorption of water and organic vapors on valnemulin hydrochloride was determined by dynamic vapor sorption at 25 °C. The adsorption-desorption behavior of water vapor and a series of organic vapors was investigated to probe the structural changes in valnemulin hydrochloride before and after sorption. The isothermal adsorption equilibrium data was evaluated using Guggenheim-Anderson-deBoer (GAB) and Brunauer-Emmett-Teller (BET) models. The BET model is applicable only at low relative pressures (0.1≤RP≤0.4) while the GAB model is applicable in the whole range of RPs (0.1≤RP≤0.9). The sorption kinetics at high RPs was determined by fitting the sorption data to the Avrami equation and the sorption content vs. time relationship could be predicted by the Avrami equation. Finally, the possible sorption mechanism of valnemulin hydrochloride was also discussed.

Key words： valnemulin hydrochloride; water vapor; organic vapors; sorption; kinetics

Acknowledgments

This research was financially supported by National Natural Science Foundation of China (Grant No. 21376165) and the Key Project of Tianjin Science and Technology Supporting Program (No. 13ZCZDNC02000).

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