%A LIU Xinhua, WANG Shifan, SONG Baoan
%T Synthesis and bactericidal activities of novel pyrazole-1-carbothioamide derivatives
%0 Journal Article
%D 2007
%J Front. Chem. China
%J Frontiers of Chemistry in China
%@ 1673-3495
%R 10.1007/s11458-007-0057-x
%P 311-314
%V 2
%N 3
%U {https://journal.hep.com.cn/fcc/EN/10.1007/s11458-007-0057-x
%8 2007-09-05
%X 4-(2-Hydroxy-phenyl)-but-3-en-2-one (1) was prepared via condensation of salicylaldehyde with acetone, and then reaction of the ketone 1 with thiosemicarbazide was accompanied by cyclization to give substituted pyrazole (2). Seven new 5-(2-hydroxy-phenyl)-3-methyl-4,5-dihydropyrazole-1-carbothioamide derivatives (3a-3g) were synthesized by the acylation of 2 and characterized by means of elemental analysis, infrared (IR), and 1H nuclear magnetic resonance (NMR). The compounds 3c, 3d, and 3g showed certain bactericidal activity against E. coli; while compound 3g showed certain bactericidal activity against P. vulgaris.