%A LIU Xinhua, WANG Shifan, SONG Baoan %T Synthesis and bactericidal activities of novel pyrazole-1-carbothioamide derivatives %0 Journal Article %D 2007 %J Front. Chem. China %J Frontiers of Chemistry in China %@ 1673-3495 %R 10.1007/s11458-007-0057-x %P 311-314 %V 2 %N 3 %U {https://journal.hep.com.cn/fcc/EN/10.1007/s11458-007-0057-x %8 2007-09-05 %X 4-(2-Hydroxy-phenyl)-but-3-en-2-one (1) was prepared via condensation of salicylaldehyde with acetone, and then reaction of the ketone 1 with thiosemicarbazide was accompanied by cyclization to give substituted pyrazole (2). Seven new 5-(2-hydroxy-phenyl)-3-methyl-4,5-dihydropyrazole-1-carbothioamide derivatives (3a-3g) were synthesized by the acylation of 2 and characterized by means of elemental analysis, infrared (IR), and 1H nuclear magnetic resonance (NMR). The compounds 3c, 3d, and 3g showed certain bactericidal activity against E. coli; while compound 3g showed certain bactericidal activity against P. vulgaris.