Spatial omics accelerate the study of cancer-associated fibroblasts in non-small lung cancer

Haozhen Liu , Jixian Liu , Chao Chen

Clinical and Translational Discovery ›› 2024, Vol. 4 ›› Issue (2) : e285

PDF
Clinical and Translational Discovery ›› 2024, Vol. 4 ›› Issue (2) :e285 DOI: 10.1002/ctd2.285
COMMENTARY

Spatial omics accelerate the study of cancer-associated fibroblasts in non-small lung cancer

Author information +
History +
PDF

Cite this article

Download citation ▾
Haozhen Liu, Jixian Liu, Chao Chen. Spatial omics accelerate the study of cancer-associated fibroblasts in non-small lung cancer. Clinical and Translational Discovery, 2024, 4(2): e285 DOI:10.1002/ctd2.285

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates cancer progression. Cancer Res. 2019;79:4557-4566.

[2]

Lo A, Wang L-CS, Scholler J, et al. Tumor-promoting desmoplasia is disrupted by depleting FAP-expressing stromal cells. Cancer Res. 2015;75(14):2800-2810.

[3]

Ford K, Hanley CJ, Mellone M, et al. NOX4 Inhibition potentiates immunotherapy by overcoming cancer-associated fibroblast-mediated CD8 T-cell exclusion from tumors. Cancer Res. 2020;80(9):1846-1860.

[4]

Narra K, Mullins SR, Lee H-O, et al. Phase II trial of single agent Val-Boropro (Talabostat) inhibiting fibroblast activation protein in patients with metastatic colorectal cancer. Cancer Biol Ther. 2007;6(11):1691-1699.

[5]

Lambrechts D, Wauters E, Boeckx B, et al. Phenotype molding of stromal cells in the lung tumor microenvironment. Nat Med. 2018;24(8):1277-1289.

[6]

Kim N, Kim HK, Lee K, et al. Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma. Nat Commun. 2020;11(1):2285.

[7]

Wu F, Fan J, He Y, et al. Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer. Nat Commun. 2021;12(1):2540.

[8]

Chen C, et al. Single-cell and spatial transcriptomics reveal POSTN(+) cancer-associated fibroblasts correlated with immune suppression and tumour progression in non-small cell lung cancer. Clin Transl Med. 2023;13:E1515.

[9]

Chen A, Liao S, Cheng M, et al. Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays. Biorxiv. 2021.

[10]

Li Z, et al. Presence of onco-fetal neighborhoods in hepatocellular carcinoma is associated with relapse and response to immunotherapy. Nat Cancer. 2024;5:167-186.

RIGHTS & PERMISSIONS

2024 The Authors. Clinical and Translational Discovery published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

AI Summary AI Mindmap
PDF

147

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/