The Golgi Ca²⁺ stores, and original contributions by Prof. Shao Bai Xue

Abstract

The Golgi apparatus serves as a distinct part of intracellular Ca²⁺ stores. Here, the early discovery by Professor Shao Bai Xue is reviewed, and the recent progress in the field is outlined. Golgi Ca²⁺ stores-related functional proteins, such as secretory pathway Ca²⁺ ATPases (SPCA1/2) and the Golgi-specific Ca²⁺ releasing channel Golgi anti-apoptotic protein (GAAP), as well as the recently defined Golgi-specific Ca²⁺ release agent emetine, collectively corroborate the concept of the Golgi apparatus as unique internal Ca²⁺ stores.

Graphical abstract

Keywords

Golgi apparatus / Ca²⁺ stores / Secretory pathway Ca²⁺ ATPase (SPCA) / Golgi anti-apoptotic protein (GAAP) / Emetine