A review for cell-based screening methods in drug discovery
Biophysics Reports ›› 2021, Vol. 7 ›› Issue (6) : 504 -516.
), Xilan Gou
With the biological relevance of the whole cells, low cost compared with animal experiments, a wide variety of cell-based screening platforms (cell-based assay, cell-based microfluidics, cell-based biosensor, cell-based chromatography) have been developed to address the challenges of drug discovery. In this review, we conclude the current advances in cell-based screening and summary the pros and cons of the platforms for different applications. Challenges and improvement strategies associated with cell-based methods are also discussed.
Cell-based screening / Drug candidate / Microfluidics / Biosensor / Affinity chromatography
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