The gut–liver axis calibrates PEDF production for ISC homeostasis

Ying Huang, Xinran Wang, Lulu Sun

Biophysics Reports ›› 2024, Vol. 10 ›› Issue (3) : 175-177.

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Biophysics Reports ›› 2024, Vol. 10 ›› Issue (3) : 175-177. DOI: 10.52601/bpr.2024.240904
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The gut–liver axis calibrates PEDF production for ISC homeostasis

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Ying Huang, Xinran Wang, Lulu Sun. The gut–liver axis calibrates PEDF production for ISC homeostasis. Biophysics Reports, 2024, 10(3): 175‒177 https://doi.org/10.52601/bpr.2024.240904

References

[1]
Andreu-Agulló C , Morante-Redolat JM , Delgado AC , Fariñas I . Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone. Nat Neurosci, 2009, 12(12): 1514–1523
CrossRef Google scholar
[2]
Brook N , Brook E , Dharmarajan A , Chan A , Dass CR . Pigment epithelium-derived factor regulation of neuronal and stem cell fate. Exp Cell Res, 2020, 389(2): 111891
CrossRef Google scholar
[3]
Chen L , Jiao T , Liu W , Luo Y , Wang J , Guo X , Tong X , Lin Z , Sun C , Wang K , He Y , Zhang Y , Xu H , Wang J , Zuo J , Ding Q , He S , Gonzalez FJ , Xie C . Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal. Cell Stem Cell, 2022, 29(9): 1366–1381
CrossRef Google scholar
[4]
Gäbele E , Dostert K , Hofmann C , Wiest R , Schölmerich J , Hellerbrand C , Obermeier F . DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH. J Hepatol, 2011, 55(6): 1391–1399
CrossRef Google scholar
[5]
Han H , Jiang Y , Wang M , Melaku M , Liu L , Zhao Y , Everaert N , Yi B , Zhang H . Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): focusing on the gut–liver axis. Crit Rev Food Sci Nutr, 2023, 63(12): 1689–1706
CrossRef Google scholar
[6]
Hegyi P , Maléth J , Walters JR , Hofmann AF , Keely SJ . Guts and gall: bile acids in regulation of intestinal epithelial function in health and disease. Physiol Rev, 2018, 98(4): 1983–2023
CrossRef Google scholar
[7]
Jones GR , Bain CC , Fenton TM , Kelly A , Brown SL , Ivens AC , Travis A , Cook PC , MacDonald AS . Dynamics of colon monocyte and macrophage activation during colitis. Front Immunol, 2018, 9: 2764
CrossRef Google scholar
[8]
Kim G , Chen Z , Li J , Luo J , Castro-Martinez F , Wisniewski K , Cui Y , Wang J , Sun X , Ren SE , Crawford SP , Becerra J , Zhu T , Liu S , Wang K , Zhao C . Gut-liver axis calibrates intestinal stem cell fitness. Cell, 2024, 187(4): 914–930
CrossRef Google scholar
[9]
Koning M , Herrema H , Nieuwdorp M , Meijnikman AS . Targeting nonalcoholic fatty liver disease via gut microbiome-centered therapies. Gut Microbes, 2023, 15(1): 2226922
CrossRef Google scholar
[10]
Luo Y , Xie C , Brocker CN , Fan J , Wu X , Feng L , Wang Q , Zhao J , Lu D , Tandon M , Cam M , Krausz KW , Liu W , Gonzalez FJ . Intestinal PPARα protects against colon carcinogenesis via regulation of methyltransferases DNMT1 and PRMT6. Gastroenterology, 2019, 157(3): 744–759
CrossRef Google scholar
[11]
Qi Y , Jiang C , Tanaka N , Krausz KW , Brocker C , Fang ZZ , Bredell BX , Shah YM , Gonzalez FJ . PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate. Am J Physiol Gastrointest Liver Physiol, 2014, 307(5): G564–573
CrossRef Google scholar
[12]
van der Flier LG , Clevers H . Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol, 2009, 71: 241–260
CrossRef Google scholar
[13]
Wigg AJ , Roberts-Thomson IC , Dymock RB , McCarthy PJ , Grose RH , Cummins AG . The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis. Gut, 2001, 48: 206–211
CrossRef Google scholar
[14]
Wu N , Sun H , Zhao X , Zhang Y , Tan J , Qi Y , Wang Q , Ng M , Liu Z , He L , Niu X , Chen L , Liu Z , Li H.-B , Zeng YA , Roulis M , Liu D , Cheng J , Zhou B , Ng LG , Zou D , Ye Y , Flavell RA , Ginhoux F , Su B . MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature, 2021, 592(7855): 606–610
CrossRef Google scholar
[15]
Yang M , Xu D , Liu Y , Guo X , Li W , Guo C , Zhang H , Gao Y , Mao Y , Zhao J . Combined serum biomarkers in non-invasive diagnosis of non-alcoholic steatohepatitis. PloS One, 2015, 10(6): e0131664
CrossRef Google scholar
[16]
Yilmaz Y , Eren F , Ayyildiz T , Colak Y , Kurt R , Senates E , Tuncer I , Dolar E , Imeryuz N . Serum pigment epithelium-derived factor levels are increased in patients with biopsy-proven nonalcoholic fatty liver disease and independently associated with liver steatosis. Clin Chim Acta Int J Clin Chem, 2011, 412(23-24): 2296–2299
CrossRef Google scholar

Compliance with ethics guidelines

Conflict of interestYing Huang, Xinran Wang and Lulu Sun declare that they have no conflict of interest. Human and animal rights and informed consent This article does not contain any studies with human or animal subjects performed by any of the authors. Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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2024 The Author(s) 2024. Published by Higher Education Press. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0)
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