An umbrella review of Lianhua Qingwen combined with Western medicine for the treatment of coronavirus disease 2019

Abstract

Objective:Lianhua Qingwen combined with Western medicine (LHQW+WM) has been proposed as a viable treatment for coronavirus disease 2019 (COVID-19). Interestingly, umbrella reviews of systematic reviews (SRs), which provide the most comprehensive evidence, are the best evidence in evidence-based medicine. Therefore, an umbrella review of SRs that summarizes and evaluates the efficacy of LHQW+WM for COVID-19 is urgently required. Methods: Overall, 6 databases were used to conduct a comprehensive literature search from inception to January 22, 2022. The corrected covered area (CCA) was used to analyze the overlapping between SRs. Meta-analysis was conducted when that of the included SRs was inappropriate. A MeaSurement Tool to Assess Systematic Reviews (AMSTAR-2) was also employed to assess the quality of the included SRs. Results:In total, 12 SRs were identified, which included 12 unique primary studies. The included SRs ranged in quality from moderate to critically low and had an extremely high CCA (36.4%). Compared to conventional treatment, LHQW+WM showed efficacy concerning fatigue recovery[risk ratio (RR) = 1.69, 95% confidence interval (CI): 1.04-2.73, n = 2, I² = 0%], cough recovery (RR = 1.65, 95% CI: 1.09-2.51, n = 3, I² = 39.1%), and overall effective rates (RR = 1.17, 95% CI: 1.07-1.28, n = 3, I² = 17.5%). Conclusion: LHQW+WM may improve the clinical symptoms of patients with COVID-19; however, the results should be interpreted cautiously because of the rigorous processes in the included SRs.

Keywords

COVID-19 / Lianhua Qingwen / Meta-analysis / Umbrella review

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