Home  Journals Subscription Open Access About Us
Just Accepted  |  Online First  |  Current Issue  |  Archive  |  Special Issues  |  Featured Articles  |  Most Downloaded

ISSN 2096-0689
CN 11-9363/R (Online)
  About the Journal
    » Aims & Scope
    » Description
    » Publication Formats
    » Editorial Board
    » Abstracting / Indexing
    » Contact us
    » Online Submission
    » Guidelines for Authors
    » Download Templates
    » Author FAQs
    » Guidelines for Reviewers
    » Online Peer Review
    » To be a Reviewer
    » Acknowledgement
Please wait a minute...
For Selected: View Abstracts Toggle Thumbnails
N-methyl-D-aspartate glutamate receptors (NMDARs) in stroke pathogenesis and treatments
Wenlin Chen, Yang Ge, Yutian Wang
Journal of Translational Neuroscience.  2019, 4 (4): 1-12.   https://doi.org/10.3868/j. issn. 2096-0689. 2019. 04. 001
Abstract   PDF (15844KB)
N-methyl-D-aspartate glutamate receptors (NMDARs) play crucial roles in the pathogenesis of neuronal injuries following a stroke insult; therefore, a plethora of preclinical studies focus on better understanding functions of NMDARs and their associated signaling pathways. Over the past decades, NMDARs have been found to exert dual effects in neuronal deaths signaling and neuronal survival signaling during cerebral ischemia. Moreover, many complex intracellular signaling pathways downstream of NMDAR activation have been elucidated, which provide novel targets for developing much-needed neuro-protectants for patients with stroke. In this review, we will discuss the recent progress in understanding the underlying mechanisms of stroke related to NMDAR activation and the potential therapeutic strategies based on these discoveries.
Related Articles | Metrics
Page 1 of 1 1 records
Copyright © 2014 Higher Education Press, All Rights Reserved. Powered by Beijing Magtech Co. Ltd
京ICP备12020869号-1 京ICP证150856号  京公网安备 11010202008535号
Service: 010-58556313 (Technology); 010-58556485 (Subscription) E-mail: subscribe@hep.com.cn