Please wait a minute...
 Home  Journals Subscription Open Access About Us
中文
 
Just Accepted  |  Online First  |  Current Issue  |  Archive  |  Special Issues  |  Featured Articles  |  Most Downloaded
Journal of Translational Neuroscience    2019, Vol. 4 Issue (4) : 13-22     https://doi.org/10.3868/j. issn. 2096-0689. 2019. 04. 002
Review
Advances in research on neuromyelitis optica spectrum disorders and its clinical heterogeneity
Yi Bao*, Ming Jin, Qi Zhao, Lu Liu, Yanpeng Sun, Xiaoqin Peng, Lu Yang, Guangjian Liu
Department of Neurology, Taihe Hospital Affiliated to Hubei University of Medicine, Shiyan 442000, China
Download: PDF(12087 KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Abstract Neuromyelitis optica spectrum disorders (NMOSD) is a demyelinating disease mainly involving the optic nerve and spinal cord. It has recurrent and aggravating attacks and high disability rate. Most patients have a stepwise progression, resulting in complete blindness or paraplegia. NMOSD lesions contain not only the optic nerve and spinal cord, but also other neurological and non-neurological symptoms, which has clinical heterogeneity. The discovery of aquaporin-4-immunoglobulin G (AQP4-IgG) attributed it to autoimmune ion-channel disease, and rituximab (RTX) has achieved good clinical efficacy in the treatment of NMOSD. Myelin oligodendrocyte glycoprotein (MOG) antibodies have been found in some AQP4-IgG-negative NMOSD patients, which have different clinical and immunological features, posing new challenges to the diagnosis and treatment of NMOSD, which may require re-design and testing of new immune-targeted drugs.
Keywords neuromyelitis optica spectrum disorders (NMOSD)      aquaporin-4-immunoglobulin G (AQP4-IgG)      myelin oligodendrocyte glycoprotein (MOG)      rituximab (RTX)      paraneoplastic neurological syndrome     
Issue Date: 23 May 2020
 Cite this article:   
Yi Bao, Ming Jin, Qi Zhao, Lu Liu, Yanpeng Sun, Xiaoqin Peng, Lu Yang, Guangjian Liu. Advances in research on neuromyelitis optica spectrum disorders and its clinical heterogeneity[J]. Journal of Translational Neuroscience,2019, 4(4): 13-22.
 URL:  
http://journal.hep.com.cn/jtn/EN/10.3868/j. issn. 2096-0689. 2019. 04. 002
http://journal.hep.com.cn/jtn/EN/Y2019/V4/I4/13
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
Copyright © 2014 Higher Education Press, All Rights Reserved. Powered by Beijing Magtech Co. Ltd
京ICP备12020869号-1 京ICP证150856号  京公网安备 11010202008535号
Service: 010-58556313 (Technology); 010-58556485 (Subscription) E-mail: subscribe@hep.com.cn