Please wait a minute...
 Home  Journals Subscription Open Access About Us
中文
 
Just Accepted  |  Online First  |  Current Issue  |  Archive  |  Special Issues  |  Featured Articles  |  Most Downloaded
Journal of Translational Neuroscience    2019, Vol. 4 Issue (3) : 24-36     https://doi.org/10.3868/j. issn. 2096-0689. 2019. 03. 003
Review
Parkinson’s disease: how should we consider the selectivity and progressivity of its neuropathology?
Wei Li1, Xiaohan Yu1, Shun Yu1,2,3,4*
1. Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
2. Clinical Center for Parkinson’s Disease, Capital Medical University, Beijing 100053, China
3. Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing 100053, China
4. National Clinical Research Center for Geriatric Disorders, Beijing 100053, China
Download: PDF(16284 KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Abstract Parkinson’s disease (PD) is a common age-related neurodegenerative disease characterized by movement disorders. The hallmark pathological lesions of PD are the formation of Lewy pathology in selected populations of neurons throughout the nervous system. Braak and his colleagues created a staging system for PD describing the connection between Lewy pathology and disease severity. They proposed that Lewy pathology might be initially triggered by exogenous pathogens targeting the enteric or olfactory nervous system, then spread in a prion-like propagation manner from the peripheral nerves to the lower brainstem and midbrain, before finally reaching higher cortical structures, causing a sequential occurrence of the non-motor and motor symptoms, depending on the lesioned neurons. However, emerging evidence also supports a functional threshold hypothesis proposed by Engelender and Isacson in which Lewy pathology may occur parallelly in the central and peripheral nervous systems and the symptoms only begin when the functional reserve of the affected neurons (and their connecting brain regions) is unable to allow for network compensation. Consequently, early symptoms of PD reflect the loss of function in the least compensated systems, such as the enteric and olfactory nervous systems, rather than the spread of Lewy pathology from the peripheral to the central nervous systems. The current review article provides a comprehensive overview of the evidence supporting a merged mechanism that the neurodegeneration in PD happens to those neurons that are not only intrinsically vulnerable but also affected by the spread of Lewy pathology.
Keywords Parkinson’s disease (PD)      Lewy body(LB)      α-synuclein (α-syn) motor symptom       non-motor symptom     
Issue Date: 23 March 2020
 Cite this article:   
Wei Li, Xiaohan Yu, Shun Yu, . Parkinson’s disease: how should we consider the selectivity and progressivity of its neuropathology?[J]. Journal of Translational Neuroscience,2019, 4(3): 24-36.
 URL:  
http://journal.hep.com.cn/jtn/EN/10.3868/j. issn. 2096-0689. 2019. 03. 003
http://journal.hep.com.cn/jtn/EN/Y2019/V4/I3/24
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Related articles from Frontiers Journals
[1] Qihan Song, Wenjiao Yu, Shun Yu, . Alpha-synuclein in body fluids as a diagnostic biomarker for Parkinson’s disease[J]. Journal of Translational Neuroscience, 2019, 4(3): 14-23.
[2] Hanjiang Luo, Min Chen, Shun Yu, . Pathogenic roles of alpha-synuclein in Parkinson’s disease and multiple system atrophy[J]. Journal of Translational Neuroscience, 2019, 4(3): 1-13.
[3] Yilun Ge, Kai Li, Chunfeng Liu. Genetic factors associated with non-motor symptoms in Parkinson’s disease[J]. Journal of Translational Neuroscience, 2019, 4(1): 15-29.
[4] Ge Gao, Hui Yang. Brain insulin resistance and Parkinson’s disease[J]. Journal of Translational Neuroscience, 2018, 3(4): 29-37.
[5] Fengxian Chen, Qinyong Ye. A review of gut microbiota and Parkinson’s disease[J]. Journal of Translational Neuroscience, 2018, 3(4): 21-28.
[6] Ting Zhang, Ke Wang, Limin Liu, Wei Wang, Li Zhang, Jun Jia, Xiaoli Gong, Xiaomin Wang. Function and mechanism of traditional Chinese medicine in the prevention and treatment of Parkinson’s disease[J]. Journal of Translational Neuroscience, 2017, 2(4): 12-23.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
Copyright © 2014 Higher Education Press, All Rights Reserved. Powered by Beijing Magtech Co. Ltd
京ICP备12020869号-1 京ICP证150856号  京公网安备 11010202008535号
Service: 010-58556313 (Technology); 010-58556485 (Subscription) E-mail: subscribe@hep.com.cn