Please wait a minute...
 Home  Journals Subscription Open Access About Us
中文
 
Just Accepted  |  Online First  |  Current Issue  |  Archive  |  Special Issues  |  Featured Articles  |  Most Downloaded
Journal of Translational Neuroscience    2019, Vol. 4 Issue (3) : 14-23     https://doi.org/10.3868/j. issn. 2096-0689. 2019. 03. 002
Review
Alpha-synuclein in body fluids as a diagnostic biomarker for Parkinson’s disease
Qihan Song1, Wenjiao Yu1, Shun Yu1,2,3,4*
1. Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
2. Clinical Center for Parkinson’s Disease, Capital Medical University, Beijing 100069, China
3. Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing 100053, China
4. National Clinical Research Center for Geriatric Disorders, Beijing 100053, China
Download: PDF(11330 KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Abstract Parkinson’s disease (PD) is a common neurodegenerative disease, characterized clinically by both motor and non-motor symptoms. Pathologically, PD is hallmarked by the loss of dopaminergic neurons in the substantia nigra (SN) and the formation of α-synuclein (α-syn) containing inclusion bodies (Lewy pathology) in the surviving neurons. Diagnosis of PD is still based on clinical features. However, owing to the complexity, heterogeneity, and overlapping of its symptoms with other Parkinsonian disorders, correct diagnosis of PD remains a challenge, especially in the early stages. Therefore, there is an urgent need for biomarkers that can help correctly diagnose PD, differentiate PD from other Parkinsonian disorders, monitor the progression of the disease, and evaluate the therapeutic efficacy. Various molecules have been investigated for their utility in diagnosing PD, among which α-syn is the most extensively investigated one due to its close implication in the etiology and pathogenesis of PD and related diseases. During the past decade, various species of α-syn, including total, oligomeric, and phosphorylated α-syn in various tissues, have been investigated for their utility as a potential biomarker for PD diagnosis and differential diagnosis. Various forms of α-syn in body fluids, including cerebrospinal fluid (CSF), blood plasma, and saliva, are among the ones that are extensively investigated, since the body fluids are relatively accessible compared to the peripheral tissues. The aim of this review is to summarize the progress of studies on the utility of α-syn in body fluid as a biomarker for PD diagnosis and differential diagnosis.
Keywords Parkinson’s disease (PD)      biomarker      alpha-synuclein (α-syn)      body fluid     
Issue Date: 23 March 2020
 Cite this article:   
Qihan Song, Wenjiao Yu, Shun Yu, . Alpha-synuclein in body fluids as a diagnostic biomarker for Parkinson’s disease[J]. Journal of Translational Neuroscience,2019, 4(3): 14-23.
 URL:  
http://journal.hep.com.cn/jtn/EN/10.3868/j. issn. 2096-0689. 2019. 03. 002
http://journal.hep.com.cn/jtn/EN/Y2019/V4/I3/14
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Related articles from Frontiers Journals
[1] Wei Li, Xiaohan Yu, Shun Yu, . Parkinson’s disease: how should we consider the selectivity and progressivity of its neuropathology?[J]. Journal of Translational Neuroscience, 2019, 4(3): 24-36.
[2] Hanjiang Luo, Min Chen, Shun Yu, . Pathogenic roles of alpha-synuclein in Parkinson’s disease and multiple system atrophy[J]. Journal of Translational Neuroscience, 2019, 4(3): 1-13.
[3] Ge Gao, Hui Yang. Brain insulin resistance and Parkinson’s disease[J]. Journal of Translational Neuroscience, 2018, 3(4): 29-37.
[4] Fengxian Chen, Qinyong Ye. A review of gut microbiota and Parkinson’s disease[J]. Journal of Translational Neuroscience, 2018, 3(4): 21-28.
[5] Ting Zhang, Ke Wang, Limin Liu, Wei Wang, Li Zhang, Jun Jia, Xiaoli Gong, Xiaomin Wang. Function and mechanism of traditional Chinese medicine in the prevention and treatment of Parkinson’s disease[J]. Journal of Translational Neuroscience, 2017, 2(4): 12-23.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
Copyright © 2014 Higher Education Press, All Rights Reserved. Powered by Beijing Magtech Co. Ltd
京ICP备12020869号-1 京ICP证150856号  京公网安备 11010202008535号
Service: 010-58556313 (Technology); 010-58556485 (Subscription) E-mail: subscribe@hep.com.cn