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Journal of Translational Neuroscience    2019, Vol. 4 Issue (1) : 15-29     https://doi.org/10.3868/j. issn. 2096-0689. 2019. 01. 002
Review
Genetic factors associated with non-motor symptoms in Parkinson’s disease
Yilun Ge1, Kai Li1, Chunfeng Liu1,2*
1.Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China
2.Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215004, China
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Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. It is a complex syndrome with heterogeneous aetiologies, pathogenesis and manifestations. Patients with PD may present with motor symptoms and various non-motor symptoms (NMSs). NMSs have been reported in almost every diagnosed case of PD and usually precede motor symptoms. Multiple factors have been proved to be associated with the occurrence of NMSs in PD, among which genetic differentiation is a featured one. With the development of sequencing techniques, an increasing number of NMS-related genetic factors have been identified. This article reviews some of the latest discoveries in this regard.
Keywords Parkinson's disease (PD)      non-motor symptoms (NMSs)      genetic differentiation     
Issue Date: 25 March 2019
 Cite this article:   
Yilun Ge, Kai Li, Chunfeng Liu. Genetic factors associated with non-motor symptoms in Parkinson’s disease[J]. Journal of Translational Neuroscience,2019, 4(1): 15-29.
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http://journal.hep.com.cn/jtn/EN/10.3868/j. issn. 2096-0689. 2019. 01. 002
http://journal.hep.com.cn/jtn/EN/Y2019/V4/I1/15
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