Genetic factors associated with non-motor symptoms in Parkinson’s disease

doi:10.3868/j. issn. 2096-0689. 2019. 01. 002

Journal of Translational Neuroscience

2019, Vol. 4

Issue (1) : 15-29 https://doi.org/10.3868/j. issn. 2096-0689. 2019. 01. 002

Review

Genetic factors associated with non-motor symptoms in Parkinson’s disease

Yilun Ge¹, Kai Li¹, Chunfeng Liu^1,2*

1.Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China
2.Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215004, China

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Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. It is a complex syndrome with heterogeneous aetiologies, pathogenesis and manifestations. Patients with PD may present with motor symptoms and various non-motor symptoms (NMSs). NMSs have been reported in almost every diagnosed case of PD and usually precede motor symptoms. Multiple factors have been proved to be associated with the occurrence of NMSs in PD, among which genetic differentiation is a featured one. With the development of sequencing techniques, an increasing number of NMS-related genetic factors have been identified. This article reviews some of the latest discoveries in this regard.

Keywords Parkinson's disease (PD) non-motor symptoms (NMSs) genetic differentiation

Issue Date: 25 March 2019

Cite this article:

Yilun Ge, Kai Li, Chunfeng Liu. Genetic factors associated with non-motor symptoms in Parkinson’s disease[J]. Journal of Translational Neuroscience,2019, 4(1): 15-29.

URL:

http://journal.hep.com.cn/jtn/EN/10.3868/j. issn. 2096-0689. 2019. 01. 002
http://journal.hep.com.cn/jtn/EN/Y2019/V4/I1/15

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