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Frontiers of Materials Science

Front Mater Sci    2012, Vol. 6 Issue (1) : 1-25     DOI: 10.1007/s11706-012-0157-5
REVIEW ARTICLE |
Scaffolds for central nervous system tissue engineering
Jin HE1, Xiu-Mei WANG1(), Myron SPECTOR2, Fu-Zhai CUI1
1. Institute for Regenerative Medicine and Biomimetic Materials, State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China; 2. Orthopedic Research Laboratory, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
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Abstract

Traumatic injuries to the brain and spinal cord of the central nervous system (CNS) lead to severe and permanent neurological deficits and to date there is no universally accepted treatment. Owing to the profound impact, extensive studies have been carried out aiming at reducing inflammatory responses and overcoming the inhibitory environment in the CNS after injury so as to enhance regeneration. Artificial scaffolds may provide a suitable environment for axonal regeneration and functional recovery, and are of particular importance in cases in which the injury has resulted in a cavitary defect. In this review we discuss development of scaffolds for CNS tissue engineering, focusing on mechanism of CNS injuries, various biomaterials that have been used in studies, and current strategies for designing and fabricating scaffolds.

Keywords central nervous system (CNS)      tissue engineering      scaffold      hydrogel     
Corresponding Authors: WANG Xiu-Mei,Email:wxm@mail.tsinghua.edu.cn   
Issue Date: 05 March 2012
 Cite this article:   
Jin HE,Xiu-Mei WANG,Myron SPECTOR, et al. Scaffolds for central nervous system tissue engineering[J]. Front Mater Sci, 2012, 6(1): 1-25.
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http://journal.hep.com.cn/foms/EN/10.1007/s11706-012-0157-5
http://journal.hep.com.cn/foms/EN/Y2012/V6/I1/1
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Jin HE
Xiu-Mei WANG
Myron SPECTOR
Fu-Zhai CUI
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