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Frontiers of Optoelectronics

Front. Optoelectron.    2009, Vol. 2 Issue (1) : 1-8     DOI: 10.1007/s12200-009-0010-3
Research articles |
Homeostatic photobiomodulation
Timon Chengyi LIU 1, Ruochun LIU 2, Ling ZHU 3, Jianqin YUAN 3, Min HU 4, Songhao LIU 5,
1.Laboratory of Laser Sports Medicine, College of Sports Science, South China Normal University, Guangzhou 510006, China;College of Life, South China Normal University, Guangzhou 510631, China; 2.College of Life, South China Normal University, Guangzhou 510631, China; 3.Laboratory of Laser Sports Medicine, College of Sports Science, South China Normal University, Guangzhou 510006, China; 4.Laboratory Center for Sport Science and Medicine, Guangzhou Institute of Physical Education, Guangzhou 510500, China; 5.School for Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510006, China;
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Abstract Photobiomodulation (PBM) is a modulation of laser irradiation or monochromatic light (LI) on biosystems, which stimulates or inhibits biological functions but does not result in irreducible damage. LI might be of low intensity LI (LIL) (about 10 mW/cm2), or moderate intensity LI (MIL) (102―103 mW/cm2). PBM of LIL or MIL (LPBM or MPBM) is studied from the homeostatic viewpoint in this paper. Homeostasis is redefined as the function-specific homeostasis (FSH), a negative-feedback response of a biosystem which maintains the function-specific conditions inside it. PBM is classified into two kinds, the FSH-specific PBM (fPBM) and developmental PBM (dPBM). For fPBM, there is no PBM of LI on the function in FSH, but there is PBM of LI on the function far from FSH. dPBM can disrupt FSH. It can be found that LPBM is an fPBM, and whether MPBM is fPBM or dPBM depends on MIL dose and cell sensitivity. Low level LI therapy is just clinical applications of fPBM, so that it is a cellular rehabilitation.
Issue Date: 05 March 2009
 Cite this article:   
Timon Chengyi LIU,Ruochun LIU,Ling ZHU, et al. Homeostatic photobiomodulation[J]. Front. Optoelectron., 2009, 2(1): 1-8.
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Timon Chengyi LIU
Ruochun LIU
Ling ZHU
Jianqin YUAN
Min HU
Songhao LIU
Campbell S S, Murphy P J. Extraocular circadian phototransductionin humans. Science, 1998, 279(5349): 396―399
Wright K P, Czeisler C A. Absence of circadian phaseresetting in response to bright light behind the knees. Science, 2002, 297(5581): 571―571
Olshausen B A, Field D J. Sparse coding of sensoryinputs. Current Opinion in Neurobiology, 2004, 14(4):481―487
Vinje W E, Gallant J L. Sparse coding and decorrelationin primary visual cortex during natural vision. Science, 2000, 287(5456): 1273―1276
Huber D, Petreanu L, Ghitani N, Ranade S, Hromádka T, Mainen Z, Svoboda K. Sparseoptical microstimulation in barrel cortex drives learned behaviourin freely moving mice. Nature, 2008, 451(7174): 61―64
Houweling A R, Brecht M. Behavioural report of singleneuron stimulation in somatosensory cortex. Nature, 2008, 451(7174): 65―68
Feuillet L, Dufour H, Pelletier J. Brain of a white-collar worker. Lancet, 2007, 370(9583): 262―262
Wang L, Zhou G B, Liu P, Song J H, Liang Y, Yan X J, Xu F, Wang B S, Mao J H, Shen Z X, Chen S J, Chen Z. Dissection of mechanismsof Chinese medicinal formula Realgar-Indigo naturalis as an effectivetreatment for promyelocytic leukemia. Proceedingsof the National Academy of Sciences of the United States of America, 2008, 105(12): 4826―4831
Liu T C Y, Jiao J L, Duan R, Li Y, Yeung Y Y, Liu S H. Membrane mechanism of low intensity laser biostimulation on a cell. In: Simunovic Z, ed. Lasers in Medicine, Surgery and Dentistry. Croatia: European MedicalLaser Association, 2003, 83―105
Liu T C Y, Jiao J L, Xu X Y, Liu X G, Deng S X, Liu S H. Photobiomodulation: phenomenology and its mechanism. Proceedings of SPIE, 2005, 5630: 185―191
Karu T. TheScience of Low-Power Laser Therapy. Amsterdam: Gordon and Breach SciencePublishers, 1998, 95―226
Tunér J, Hode L. Low Level Laser Therapy. Graengesberg: Prima Books in Sweden AB, 1999, 90―92
Yang X H, Liu C Y, Liu S J, Li S M, Shen Y, Tan J R, Liang P H. Photobiomodulation on chondrocyteproliferation: in vitro evaluation. Chinese Journal of Lasers, 2006, 33(12): 1692―1698 (in Chinese)
Funakoshi Y, Shiono H, Inoue M, Kadota Y, Ohta M, Matsuda H, Okumura M, Eimoto T. Glucocorticoids induce G1cell cycle arrest in human neoplastic thymic epithelial cells. Journal of Cancer Research and Clinical Oncology, 2005, 131(5): 314―322
Chen X Y. Studies of the effect of glucocorticoid and statins on proliferationof C2C12 myoblast and its photobiomodulation. Dissertation for the Master’s Degree. Guangzhou: South China NormalUniversity, 2008, 30―50
Bouma M G, Buurman W A, van den Wildenberg F A. Low energy laser irradiation fails tomodulate the inflammatory function of human monocytes and endothelialcells. Lasers in Surgery and Medicine, 1996, 19(2): 207―215
Lin Y S, Huang M H, Chai C Y, Yang R C. Effects ofhelium-neon laser on levels of stress protein and arthritic histopathologyin experimental osteoarthritis. AmericanJournal of Physical Medicine and Rehabilitation, 2004, 83(10): 758―765
Iijima K, Shimoyama N, Shimoyama M, Mizuguchi T. Effectof low-power He-Ne laser on deformability of stored human erythrocytes. Journal of Clinical Laser Medicine and Surgery, 1993, 11(4):185―189
Duan R, Zhu L, Liu T C, Li Y, Liu J, Jiao J, Xu X, Yao L, Liu S. Light emittingdiode irradiation protect against the amyloid beta 25-35 induced apoptosisof PC12 cell in vitro. Lasers in Surgery and Medicine, 2003, 33(3): 199―203
Eells J T, Henry M M, Summerfelt P, Wong-Riley M T, Buchmann E V, Kane M, Whelan N T, Whelan H T. Therapeutic photobiomodulationfor methanol-induced retinal toxicity. Proceedings of the National Academy of Sciences of the United Statesof America, 2003, 100(6): 3439―3444
Aimbire F, Lopes-Martins R A, Castro-Faria-Neto H C, Albertini R, Chavantes M C, Pacheco M T, Leonardo P S, Iversen V V, Bjordal J M. Low-level laser therapy can reduce lipopolysaccharide-inducedcontractile force dysfunction and TNF-α levels in rat diaphragmmuscle. Lasers in Medical Science, 2006, 21(4): 238―244
Aimbire F, Ligeiro de Oliveira A P, Albertini R, Corrêa J C, Ladeira de Campos C B, Lyon J P, Silva J A Jr, Costa M S. Low level laser therapy (LLLT)decreases pulmonary microvascular leakage, neutrophil influx and IL-1βlevels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation, 2008, 31(3): 189―197
Aimbire F, Santos F V, Albertini R, Castro-Faria-Neto H C, Mittmann J, Pacheco-Soares C. Low-level laser therapy decreases levelsof lung neutrophils anti-apoptotic factors by a NF-κB dependentmechanism. International Immunopharmacology, 2008, 8(4): 603―605
Karu T I, Ryabykh T P, Fedoseyeva G E, Puchkova N I. Helium-neon laser-induced respiratory burst of phagocytic cells. Lasers in Surgery and Medicine, 1989, 9(6): 585―588
Aimbire F, Bjordal J M, Iversen V V, Albertini R, Frigo L, Pacheco M T, Castro-Faria-Neto H C, Chavantes M C, Labat R M, Lopes-Martins R A. Low level laser therapy partially restores trachea muscle relaxationresponse in rats with tumor necrosis factor alpha-mediated smoothairway muscle dysfunction. Lasers in Surgeryand Medicine, 2006, 38(8): 773―778
Karu T I, Pyatibrat L V, Kalendo G S. Donors of NO and pulsed radiation at lambda= 820 nm exerteffects on cell attachment to extracellular matrices. Toxicology Letters, 2001, 121(1): 57―61
Wu M, Zhu L, Hu B, Liu T C Y, Rong D L, Chen T S. Effects of red light at 640nm from light emitting diodes on the respiratoryburst of human neutrophils. Journal ofInnovative Optical Health Science, 2008, 1(2): 285―294
Wu S, Xing D, Wang F, Chen T, Chen W R. Mechanistic study of apoptosis inducedby high-fluence low-power laser irradiation using fluorescence imagingtechniques. Journal of Biomedical Optics, 2007, 12(6): 064015
Zhang J, Xing D, Gao X. Low-power laser irradiation activates Src tyrosine kinasethrough reactive oxygen species-mediated signaling pathway. Journal of Cellular Physiology, 2008, 217(2): 518―528
Fujimaki Y, Shimoyama T, Liu Q, Umeda T, Nakaji S, Sugawara K. Low-levellaser irradiation attenuates production of reactive oxygen speciesby human neutrophils. Journal of ClinicalLaser Medicine and Surgery, 2003, 21(3):165―170
Djavaheri-Mergny M, Dubertret L. UV-A-induced AP-1 activationrequires the Raf/ERK pathway in human NCTC 2544 keratinocytes. Experimental Dermatology, 2001, 10(3): 204―210
Fujihara N A, Hiraki K R, Marques M M. Irradiation at 780 nm increases proliferation rate ofosteoblasts independently of dexamethasone presence. Lasers in Surgery and Medicine, 2006, 38(4): 332―336
Oliveira N M, Parizzotto N A, Salvini T F. GaAs (904-nm) laser radiation does not affect muscleregeneration in mouse skeletal muscle. Lasers in Surgery and Medicine, 1999, 25(1):13―21
Amaral A C, Parizotto N A, Salvini T F. Dose-dependency of low-energy HeNe laser effect in regenerationof skeletal muscle in mice. Lasers in MedicineScience, 2001, 16(1):44―51
Morrone G, Guzzardella G A, Tigani D, Torricelli P, Fini M, Giardino R. Biostimulation of human chondrocytes with Ga-Al-As diodelaser: ‘in vitro’ research. Artificial Cells, Blood Substitutes, and ImmobilizationBiotechnology, 2000, 28(2): 193―201
Shefer G, Partridge T A, Heslop L, Gross J G, Oron U, Halevy O. Low-energylaser irradiation promotes the survival and cell cycle entry of skeletalmuscle satellite cells. Journal of CellScience, 2002, 115(Pt 7): 1461―1469
Carnevalli C M, Soares C P, Zângaro R A, Pinheiro A L, Silva N S. Laser light prevents apoptosisin Cho K-1 cell line. Journal of ClinicalLaser Medicine and Surgery, 2003, 21(4):193―196
Mi X Q, Chen J Y, Cen Y, Liang Z J, Zhou L W. A comparative study of 632.8 and 532?nmlaser irradiation on some rheological factors in human blood in vitro. Journalof Photochemistry and Photobiology B, 2004, 74(1): 7―12
Wang T D, Dong W R, Xiao Y Q, Lin Y Q, Yi G H, Wei P, Wang D H. Effects of low-energy He-Nelaser irradiation of extracorporeally circulatory blood on ATPaseactivities of erythrocyte membrane in patients with IDDM. Laser Journal, 1992, 13(6): 324―327 (in Chinese)
Farkhutdinov U R. Intravascular laser irradiation of blood in the treatment of patientswith bronchial asthma. TerapevticheskiiArkhiv, 2007, 79(3): 44―48
Cemek M, Caksen H, Bayiroğlu F, Cemek F, Dede S. Oxidative stress and enzymic-non-enzymicantioxidant responses in children with acute pneumonia. Cell Biochemistry and Function, 2006, 24(3): 269―273
Mitsunobu F, Yamaoka K, Hanamoto K, Kojima S, Hosaki Y, Ashida K, Sugita K, Tanizaki Y. Elevation of antioxidantenzymes in the clinical effects of radon and thermal therapy for bronchialasthma. Journal of Radiation Research (Tokyo), 2003, 44(2): 95―99
Xiao X C, Guo Y L, Chu X F, Jia S W, Zheng X Y, Zhou C X. Effects of low power laser irradiation in nasal cavity on cerebralblood flow perfusion of patients with brain infarction. Chinese Journal of Physical Medicine and Rehabilitation, 2005, 27(7): 418―420 (in Chinese)
Kipshidze N, Keelan M H Jr, Horn J B, Nikolaychik V. Photobiomodulationof vascular endothelial and smooth muscle cells in vitro with red laser light. Proceedings of SPIE, 1996, 2922: 422―430
Korogodin V I, Korogodina V L. Small doses and cell rehabilitation. Russian Journal of Ecology, 1997, 28 (1): 20―24
Wang X L, Song M, Lou J N, Niu X Y. The studyof cytotoxicity of different intracanal medications and cell rehabilitationon human periodontal ligament fibroblasts. Shanghai Journal of Stomatology, 2007, 16(5): 512―519 (in Chinese)
Day R N, Schaufele F. Fluorescent protein toolsfor studying protein dynamics in living cells: a review. Journal of Biomedical Optics, 2008, 13(3): 031202
Gao X, Chen T, Xing D, Wang F, Pei Y, Wei X. Singlecell analysis of PKC activation during proliferation and apoptosisinduced by laser irradiation. Journal ofCellular Physiology, 2006, 206(2): 441―448
Hübscher M, Vogt L, Banzer W. Laser needle acupuncture at Neiguan (PC6) does not mediateheart rate variability in young, healthy men. Photomedicine and Laser Surgery, 2007, 25(1): 21―25
Wu J H, Chen H Y, Chang Y J, Wu H C, Chang W D, Chu Y J, Jiang J A. Study of autonomic nervousactivity of night shift workers treated with laser acupuncture. Photomedicine and Laser Surgery, 2008, 26(6): 665―669
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