%A Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng %T Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis %0 Journal Article %D 2012 %J Front. Med. %J Frontiers of Medicine %@ 2095-0217 %R 10.1007/s11684-012-0216-4 %P 275-279 %V 6 %N 3 %U {https://journal.hep.com.cn/fmd/EN/10.1007/s11684-012-0216-4 %8 2012-09-05 %X

PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses to hormones and cytokines. Against original prediction as tumor suppressor for tyrosine phosphatases, PTPN11 was first identified as a proto-oncogene because activating mutations of this gene are associated with leukemogenesis. However, most recent experimental data suggest PTPN11/Shp2 acting as a tumor suppressor in hepatocarcinogenesis. This review focuses on the tumor-promoting or suppressing roles of the gene PTPN11/Shp2 in different cell types.