Please wait a minute...

Frontiers of Medicine

Front. Med.    2020, Vol. 14 Issue (2) : 113-116     https://doi.org/10.1007/s11684-020-0758-9
EDITORIAL
Back to the spring of 2020: facts and hope of COVID-19 outbreak
Guangbiao Zhou1(), Saijuan Chen2(), Zhu Chen2
1. State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
2. State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine (Shanghai), Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Download: PDF(402 KB)   HTML
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Corresponding Authors: Guangbiao Zhou,Saijuan Chen   
Just Accepted Date: 21 February 2020   Online First Date: 16 March 2020    Issue Date: 09 May 2020
 Cite this article:   
Guangbiao Zhou,Saijuan Chen,Zhu Chen. Back to the spring of 2020: facts and hope of COVID-19 outbreak[J]. Front. Med., 2020, 14(2): 113-116.
 URL:  
http://journal.hep.com.cn/fmd/EN/10.1007/s11684-020-0758-9
http://journal.hep.com.cn/fmd/EN/Y2020/V14/I2/113
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Guangbiao Zhou
Saijuan Chen
Zhu Chen
Fig.1  Back to the spring of 2020. Sakura garden of East Lake Wuhan, 2019. Courtesy of Mr. Zhenyin Chen, a postgraduate student of Guizhou University.
Fig.2  A brief timeline of the COVID-19 outbreak. ICTV, International Committee on Taxonomy of Viruses; NHC, National Health Commission; WHO, World Health Organization.
China Other countries
Wuhan Other regions Total
Total cases* 45 346 30 221 75 567 1151
Disease severity
Non-severe, n (%) 34 034 (75.1%) 27 661 (91.5%) 61 695 (81.6%)
Severe, n (%) 9628 (21.2%) 2005 (6.6%) 11 633 (15.4%)
Mortality, n (%) 1684 (3.7%) 555 (1.8%) 2239 (3.0%) 8 (0.6%)
Tab.1  Comparison of disease severity and mortality in patients from different regions or countries
1 N Zhu, D Zhang, W Wang, X Li, B Yang, J Song, X Zhao, B Huang, W Shi, R Lu, P Niu, F Zhan, X Ma, D Wang, W Xu, G Wu, GF Gao, W Tan; China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020; 382(8): 727–733
https://doi.org/10.1056/NEJMoa2001017 pmid: 31978945
2 AE Gorbalenya, SC Baker, RS Baric, RJ de Groot, C Drosten, AA Gulyaeva, et al.. Severe acute respiratory syndrome-related coronavirus: the species and its viruses — a statement of the Coronavirus Study Group. bioRxiv 2020; doi: 10.1101/2020.02.07.937862
https://doi.org/10.1101/2020.02.07.937862
3 S Jiang, Z Shi, Y Shu, J Song, GF Gao, W Tan, D Guo. A distinct name is needed for the new coronavirus. Lancet 2020 Feb 19. [Epub ahead of print] doi: 10.1016/S0140-6736(20)30419-0
https://doi.org/10.1016/S0140-6736(20)30419-0 pmid: 32087125
4 BJ Cowling, GM Leung. Epidemiological research priorities for public health control of the ongoing global novel coronavirus (2019-nCoV) outbreak. Euro Surveill 2020; 25(6): 2000110
https://doi.org/10.2807/1560-7917.ES.2020.25.6.2000110 pmid: 32046814
5 C Wang, PW Horby, FG Hayden, GF Gao. A novel coronavirus outbreak of global health concern. Lancet 2020; 395(10223): 470–473
https://doi.org/10.1016/S0140-6736(20)30185-9 pmid: 31986257
6 FH Gong, Y Xiong, J Xiao, L Lin, XD Liu, DZ Wang, XK Li. China’s local governments are combating COVID-19 with unprecedented responses — from a Wenzhou governance perspective. Front Med 2020 Feb 13. [Epub ahead of print] doi: 10.1007/s11684-020-0755-z
https://doi.org/10.1007/s11684-020-0755-z
7 Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China. Chin J Epidemiol (Zhonghua Liu Xing Bing Xue Za Zhi) 2020; 41(2): 145–151 (in Chinese)
pmid: 32064853
8 World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report – 29. 2020
9 C Anastassopoulou, L Russo, A Tsakris, C Siettos. Data-based analysis, modelling and forecasting of the novel coronavirus (2019-nCoV) outbreak. medRxiv 2020; doi: 10.1101/2020.02.11.20022186
https://doi.org/10.1101/2020.02.11.20022186
10 Q Li, X Guan, P Wu, X Wang, L Zhou, Y Tong, R Ren, KSM Leung, EHY Lau, JY Wong, X Xing, N Xiang, Y Wu, C Li, Q Chen, D Li, T Liu, J Zhao, M Liu, W Tu, C Chen, L Jin, R Yang, Q Wang, S Zhou, R Wang, H Liu, Y Luo, Y Liu, G Shao, H Li, Z Tao, Y Yang, Z Deng, B Liu, Z Ma, Y Zhang, G Shi, TTY Lam, JTK Wu, GF Gao, BJ Cowling, B Yang, GM Leung, Z Feng. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 2020 Jan 29. [Epub ahead of print] doi: 10.1056/NEJMoa2001316
https://doi.org/10.1056/NEJMoa2001316 pmid: 31995857
11 C Huang, Y Wang, X Li, L Ren, J Zhao, Y Hu, L Zhang, G Fan, J Xu, X Gu, Z Cheng, T Yu, J Xia, Y Wei, W Wu, X Xie, W Yin, H Li, M Liu, Y Xiao, H Gao, L Guo, J Xie, G Wang, R Jiang, Z Gao, Q Jin, J Wang, B Cao. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395(10223): 497–506
https://doi.org/10.1016/S0140-6736(20)30183-5 pmid: 31986264
12 N Chen, M Zhou, X Dong, J Qu, F Gong, Y Han, Y Qiu, J Wang, Y Liu, Y Wei, J Xia, T Yu, X Zhang, L Zhang. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020; 395(10223): 507–513
https://doi.org/10.1016/S0140-6736(20)30211-7 pmid: 32007143
13 Z Xu, L Shi, Y Wang, J Zhang, L Huang, C Zhang, S Liu, P Zhao, H Liu, L Zhu, Y Tai, C Bai, T Gao, J Song, P Xia, J Dong, J Zhao, FS Wang. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020 Feb 18. [Epub ahead of print] doi: 10.1016/S2213-2600(20)30076-X
https://doi.org/10.1016/S2213-2600(20)30076-X pmid: 32085846
14 R Lu, X Zhao, J Li, P Niu, B Yang, H Wu, W Wang, H Song, B Huang, N Zhu, Y Bi, X Ma, F Zhan, L Wang, T Hu, H Zhou, Z Hu, W Zhou, L Zhao, J Chen, Y Meng, J Wang, Y Lin, J Yuan, Z Xie, J Ma, WJ Liu, D Wang, W Xu, EC Holmes, GF Gao, G Wu, W Chen, W Shi, W Tan. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020; 395(10224): 565–574
https://doi.org/10.1016/S0140-6736(20)30251-8 pmid: 32007145
15 P Zhou, XL Yang, XG Wang, B Hu, L Zhang, W Zhang, HR Si, Y Zhu, B Li, CL Huang, HD Chen, J Chen, Y Luo, H Guo, RD Jiang, MQ Liu, Y Chen, XR Shen, X Wang, XS Zheng, K Zhao, QJ Chen, F Deng, LL Liu, B Yan, FX Zhan, YY Wang, GF Xiao, ZL Shi. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020 Feb 3. [Epub ahead of print] doi: 10.1038/s41586-020-2012-7
https://doi.org/10.1038/s41586-020-2012-7 pmid: 32015507
16 TTY Lam, MHH Shum, HC Zhu, YG Tong, XB Ni, YS Liao, et al.. Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China. bioRxiv 2020; doi:10.1101/2020.02.13.945485
17 L Zou, F Ruan, M Huang, L Liang, H Huang, Z Hong, J Yu, M Kang, Y Song, J Xia, Q Guo, T Song, J He, HL Yen, M Peiris, J Wu. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med 2020 Feb 19. [Epub ahead of print] doi: 10.1056/NEJMc2001737
https://doi.org/10.1056/NEJMc2001737 pmid: 32074444
18 M Letko, V Munster. Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV. bioRxiv 2020; doi: 10.1101/2020.01.22.915660
https://doi.org/10.1101/2020.01.22.915660
19 D Wrapp, N Wang, KS Corbett, JA Goldsmith, CL Hsieh, O Abiona, BS Graham, JS McLellan. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 2020 Feb 19. [Epub ahead of print] doi: 10.1126/science.abb2507
https://doi.org/10.1126/science.abb2507 pmid: 32075877
20 Q Zhou, R Yan, Y Zhang, Y Li, L Xia. Structure of dimeric full-length human ACE2 in complex with B0AT1. bioRxiv 2020; doi: 10.1101/2020.02.17.951848
https://doi.org/10.1101/2020.02.17.951848
21 X Zou, K Chen, JW Zou, PY Han, J Hao, ZG Han. The single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med 2020 Feb 8. [Epub ahead of print] doi: 10.1007/s11684-020-0754-0
https://doi.org/10.1007/s11684-020-0754-0
22 G Li, E De Clercq. Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Disc 2020 Feb 10. [Epub ahead of print] doi: 10.1038/d41573-020-00016-0
https://doi.org/10.1038/d41573-020-00016-0
23 M Wang, R Cao, L Zhang, X Yang, J Liu, M Xu, Z Shi, Z Hu, W Zhong, G Xiao. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 2020 Feb 4. [Epub ahead of print] doi: 10.1038/s41422-020-0282-0
https://doi.org/10.1038/s41422-020-0282-0 pmid: 32020029
24 ML Holshue, C DeBolt, S Lindquist, KH Lofy, J Wiesman, H Bruce, C Spitters, K Ericson, S Wilkerson, A Tural, G Diaz, A Cohn, L Fox, A Patel, SI Gerber, L Kim, S Tong, X Lu, S Lindstrom, MA Pallansch, WC Weldon, HM Biggs, TM Uyeki, SK Pillai; Washington State 2019-nCoV Case Investigation Team. First case of 2019 novel coronavirus in the United States. N Engl J Med 2020 Jan 31. [Epub ahead of print] doi: 10.1056/NEJMoa2001191
https://doi.org/10.1056/NEJMoa2001191 pmid: 32004427
25 Y Zhang, X Wang. 32 recovered patients donate plasma to others with coronavirus infection. China Daily 2020 Feb 16.
26 Y Zhang. Scientists target major cause of critically ill virus deaths. China Daily 2020 Feb 15.
27 C Wang, B Cao, QQ Liu, ZQ Zou, ZA Liang, L Gu, JP Dong, LR Liang, XW Li, K Hu, XS He, YH Sun, Y An, T Yang, ZX Cao, YM Guo, XM Wen, YG Wang, YL Liu, LD Jiang. Oseltamivir compared with the Chinese traditional therapy maxingshigan-yinqiaosan in the treatment of H1N1 influenza: a randomized trial. Ann Intern Med 2011; 155(4): 217–225
https://doi.org/10.7326/0003-4819-155-4-201108160-00005 pmid: 21844547
28 L Ni, L Zhou, M Zhou, J Zhao, D Wang. Combination of western medicine and Chinese patent medicine in treating a family case of COVID-19. Front Med 2020 Feb 19. [Epub ahead of print] doi: 10.1007/s11684-020-0757-x
https://doi.org/10.1007/s11684-020-0757-x
29 C Calisher, D Carroll, R Colwell, RB Corley, P Daszak, C Drosten, L Enjuanes, J Farrar, H Field, J Golding, A Gorbalenya, B Haagmans, JM Hughes, WB Karesh, GT Keusch, SK Lam, J Lubroth, JS Mackenzie, L Madoff, J Mazet, P Palese, S Perlman, L Poon, B Roizman, L Saif, K Subbarao, M Turner. Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19. Lancet 2020 Feb 19. [Epub ahead of print] doi: 10.1016/S0140-6736(20)30418-9
https://doi.org/10.1016/S0140-6736(20)30418-9 pmid: 32087122
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed