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Frontiers of Medicine

Front Med    2013, Vol. 7 Issue (1) : 132-137     DOI: 10.1007/s11684-013-0250-x
RESEARCH ARTICLE |
Association between history of abortion and metabolic syndrome in middle-aged and elderly Chinese women
Baihui Xu2, Jie Zhang2, Yu Xu1,2, Jieli Lu1,2, Min Xu1,2, Yuhong Chen1,2, Yufang Bi1,2, Guang Ning1,2()
1. The Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai 200025, China; 2. Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
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Abstract

Epidemiologic studies have suggested that abortion may cause long term health consequences such as cardiovascular disease. Until recently, studies focusing on the association between history of abortion and metabolic diseases were limited. In the present study, we aimed to investigate the association between history of abortion and metabolic syndrome (MetS) in middle-aged and elderly Chinese women. A cross-sectional survey was performed in 6302 women (age≥40 years) in Shanghai. Standardized questionnaire was used to obtain the information about reproductive histories. Overall, we observed a positive association between history of induced abortion and the prevalence of MetS, independent of potential confounding factors. A multivariable-adjusted logistic regression analysis revealed that compared to those without a history of induced abortion, women with a history of induced abortion remained at 1.25 times more likely to have MetS (OR=1.25, 95% CI=1.06–1.47, P<0.05), and the association was number-dependent. However, no significant association between history of spontaneous abortion and the prevalence of MetS was observed. Compared to those without a history of spontaneous abortion, the multivariate-adjusted odds ratio associated with a history of spontaneous abortion for MetS was 0.88 (95% CI=0.65–1.19, P >0.05).

Keywords induced abortion      spontaneous abortion      metabolic syndrome     
Corresponding Authors: Ning Guang,Email:gning@sibs.ac.cn   
Issue Date: 05 March 2013
 Cite this article:   
Baihui Xu,Jie Zhang,Yu Xu, et al. Association between history of abortion and metabolic syndrome in middle-aged and elderly Chinese women[J]. Front Med, 2013, 7(1): 132-137.
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http://journal.hep.com.cn/fmd/EN/10.1007/s11684-013-0250-x
http://journal.hep.com.cn/fmd/EN/Y2013/V7/I1/132
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Baihui Xu
Jie Zhang
Yu Xu
Jieli Lu
Min Xu
Yuhong Chen
Yufang Bi
Guang Ning
Number of abortionP for trend
012&gt;2
N (%)1850 (29.36)2616 (41.51)1444 (22.91)392 (6.22)-
Age (year)60.69±11.0956.77±8.7057.41±8.1059.12±8.27&lt;0.0001
BMI (kg/m2)24.85±3.4325.00±3.3625.22±3.3325.63±3.39&lt;0.0001
Current smoking, n (%)10 (0.54)9 (0.34)5 (0.35)3 (0.77)0.89
Current drinking, n (%)15 (0.98)17 (0.65)13 (0.90)2 (0.51)0.89
Waist circumference (cm)80.49±9.0380.58±8.6481.45±8.5882.76±8.74&lt;0.0001
SBP (mmHg)143.32±21.43140.0±20.24140.1±20.38142.6±20.660.0028
DBP (mmHg)81.35±10.5781.83±10.0681.65±9.9982.23±10.000.15
FPG (mmol/L)5.51±1.465.47±1.415.44±1.285.49±1.280.29
2h-PG (mmol/L)8.44±4.448.16±4.048.16±3.778.58±3.860.42
HOMA-IR1.65 (1.12-2.62)1.70 (1.16-2.59)1.74 (1.21-2.54)1.87 (1.27-2.86)0.002
TG (mmol/L)1.36 (0.98-1.92)1.38 (0.97-1.94)1.40 (1.03-2.00)1.48 (0.98-2.07)0.044
TC (mmol/L)5.48±1.025.46±1.085.51±0.965.57±1.030.11
LDL-C (mmol/L)3.28±0.903.26±0.903.32±0.863.39±0.910.0024
HDL-C (mmol/L)1.39±0.311.38±0.321.37±0.311.35±0.290.016
Tab.1  Baseline characteristics according to history of abortion
Fig.1  The prevalence of metabolic syndrome (MetS) in population grouped by a history of total/spontaneous/induced abortion. for trend was calculated using Cochran-Armitage trend tests. (A) The prevalence of MetS according to a history of total abortion (bar 1, non-abortion; bar 2, 1 abortion; bar 3, 2 abortions; bar 4,>2 abortions). (B) The prevalence of MetS according to a history of spontaneous abortion (bar 1, non-spontaneous abortion; bar 2, 1 spontaneous abortion; bar 3, 2 spontaneous abortions; bar 4,>2 spontaneous abortions). (C) The prevalence of MetS according to a history of induced abortion (bar 1, non-induced abortion; bar 2, 1 induced abortion; bar 3, 2 induced abortions; bar 4,>2 induced abortions).
Fig.1  The prevalence of metabolic syndrome (MetS) in population grouped by a history of total/spontaneous/induced abortion. for trend was calculated using Cochran-Armitage trend tests. (A) The prevalence of MetS according to a history of total abortion (bar 1, non-abortion; bar 2, 1 abortion; bar 3, 2 abortions; bar 4,>2 abortions). (B) The prevalence of MetS according to a history of spontaneous abortion (bar 1, non-spontaneous abortion; bar 2, 1 spontaneous abortion; bar 3, 2 spontaneous abortions; bar 4,>2 spontaneous abortions). (C) The prevalence of MetS according to a history of induced abortion (bar 1, non-induced abortion; bar 2, 1 induced abortion; bar 3, 2 induced abortions; bar 4,>2 induced abortions).
Model 1Model 2Model 3
With a history of abortion a
Total (n = 4452)1.27 (1.14-1.43)1.18 (1.01-1.38)1.20 (1.01-1.42)
1 abortion (n = 2616)1.22 (1.08-1.39)1.22 (1.04-1.43)1.23 (1.04-1.48)
2 abortions (n = 1444)1.26 (1.09-1.45)1.28 (1.01-1.61)1.28 (1.00-1.64)
&gt;2 abortions (n = 392)1.68 (1.35-2.11)1.79 (1.24-2.58)1.76 (1.19-2.62)
P for trend&lt;0.00010.00620.010
With a history of spontaneous abortion b
Total (n = 309)0.89 (0.70-1.12)0.95 (0.72-1.26)0.88 (0.65-1.19)
1 abortion (n = 249)0.90 (0.70-1.17)0.99 (0.74-1.33)0.90 (0.65-1.25)
2 abortions (n = 43)0.78 (0.42-1.46)0.78 (0.38-1.59)0.79 (0.38-1.63)
&gt;2 abortions (n = 17)0.89 (0.33-2.41)0.84 (0.28-2.52)0.79 (0.24-2.65)
P for trend0.310.590.36
With a history of induced abortion c
Total (n = 4253)1.31 (1.17-1.47)1.23 (1.05-1.44)1.25 (1.06-1.47)
1 abortion (n = 2552)1.27 (1.12-1.43)1.26 (1.08-1.48)1.28 (1.08-1.52)
2 abortions (n = 1352)1.29 (1.12-1.49)1.30 (1.03-1.64)1.31 (1.03-1.68)
&gt;2 abortions (n = 349)1.74 (1.38-2.19)1.86 (1.28-2.69)1.83 (1.23-2.72)
P for trend&lt;0.00010.00260.0049
Tab.2  Risk of prevalent MetS according to history of abortion
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