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Frontiers of Medicine

Front Med    2012, Vol. 6 Issue (1) : 41-47     DOI: 10.1007/s11684-012-0175-9
REVIEW |
Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration
Siming Yang1,2, Sha Huang1,2, Changjiang Feng2,3, Xiaobing Fu1,2()
1. Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Sciences, General Hospital of PLA, Beijing 100853, China; 2. Burns Institute, the First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing 100048, China; 3. Thoracic and Cardiovascular Surgery Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
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Abstract

Umbilical cord mesenchymal stem cells (MSCs) are a unique, accessible, and non-controversial source of early stem cells that can be readily manipulated. As the most common pluripotent cell, bone marrow-derived MSCs display limitations with the progress of stem cell therapy. By contrast, umbilical cord-derived cells, which have plentiful resources, are more accessible. However, several uncertain aspects, such as the effect of donor selection or culture conditions, long-term therapeutic effects, product consistency, and potential tumorigenicity, are the bottleneck in this clinical therapy. MSCs are predicted to undergo an unprecedented development in clinical treatment when a generally acknowledged criterion emerges. In the current paper, we highlight the application of umbilical cord-derived MSCs in skin therapies based on our previous studies, as well as the achievements of our peers in this field. This paper focuses on the strategies, challenges, and potential of this novel therapy.

Keywords umbilical cord      mesenchymal stem cells      cutaneous regeneration     
Corresponding Authors: Fu Xiaobing,Email:fuxb@cgw.net.cn; fuxiaobing@vip.sina.com   
Issue Date: 05 March 2012
 Cite this article:   
Sha Huang,Changjiang Feng,Xiaobing Fu, et al. Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration[J]. Front Med, 2012, 6(1): 41-47.
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http://journal.hep.com.cn/fmd/EN/10.1007/s11684-012-0175-9
http://journal.hep.com.cn/fmd/EN/Y2012/V6/I1/41
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Fig.1  Compartments within the umbilical cord. Mesenchymal stem cells (MSCs) can be isolated from (1) the umbilical cord blood; (2) the umbilical vein subendothelial layer; (3) the enzymatic digestion of the outer layers of the umbilical vessels; (4) the intravascular space of healthy individuals; and (5) Wharton's jelly. The current review focuses on Wharton’s jelly-derived MSCs (WJMSCs) and not on MSCs derived from the umbilical cord blood or umbilical vein subendothelium.
Cell typeSourcesGerm layerSurface markersEthical issuesGrowth kineticsSafetyDifferentiation capacityImmuno-genicityEasy to obtain
PositiveNegative
WJMSCUmbilical cord Wharton’s jellyMesoblastCD73, CD44CD105, CD90CD45,CD34NoHigherSafeHighLowerEasy to obtain. No harm to the donor. Can be used in several people
BMMSCBone marrowMesoblastCD73, CD44CD105, CD90CD45,CD34,LowHighSafeLowLowNot easy to obtain. Can harm the donor
UCBMSCUmbilical cord bloodMesoblastCD73, CD44CD105, CD90CD45,CD34NoHighSafeLowLowerEasy to obtain. No harm to the donor. Just for one child
Tab.1  Comparison of the different MSCs populations
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