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Frontiers in Biology

Front. Biol.    2016, Vol. 11 Issue (5) : 387-390     DOI: 10.1007/s11515-016-1418-y
Antibacterial effect of bestatin during periodontitis
Hansa Jain()
Department of Pedodontics, Harsarn Dass Dental College, India
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Periodontitis is a polymicrobial disease inciting inflammatory destruction of the tooth-supporting tissues, i.e., periodontium. The initiation of this infectious disease is ascribed to the formation of subgingival biofilms. These biofilms cause stimulation of myriad of chronic inflammatory reactions by the affected tissue. The Gram-negative anaerobe Porphyromonas gingivalis is commonly found as part of the microbiota of subgingival biofilms, and is involved in the occurrence of the disease. P. gingivalis possesses numerous virulence factors supporting its survival, regulating its communication with other species in the biofilm, degrading host tissues. Fusobacterium nucleatum is pivotal for formation of biofilm and promotes growth and invasion properties of P. gingivalis. Bestatin is an aminopeptide inhibitor, produced by actinomycetes. It possesses antibacterial properties against P. gingivalis and F. nucleatum. The following review focuses on action of bestatin on the mentioned bacteria.

Keywords bestatin      Porphyromonas gingivalis      Fusobacterium nucleatum      periodontitis      biofilm     
Corresponding Authors: Hansa Jain   
Online First Date: 28 September 2016    Issue Date: 04 November 2016
 Cite this article:   
Hansa Jain. Antibacterial effect of bestatin during periodontitis[J]. Front. Biol., 2016, 11(5): 387-390.
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Hansa Jain
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