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Frontiers in Biology

Front. Biol.    2018, Vol. 13 Issue (6) : 452-457     https://doi.org/10.1007/s11515-018-1515-1
RESEARCH ARTICLE |
The comparison of insulin and uric acid levels in adolescents with and without metabolic syndrome
Homeira Rashidi1, Hajieh Shahbazian1, Forogh Nokhostin2(), Seyed Mahmood Latifi1, Mehrian Jafarizade2
1. Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2. Department of internal medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
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Abstract

BACKGROUND and AIM: The prevalence of metabolic syndrome (MS) increased in recent years in both adolescents and children groups. The aim of the study is evaluating the relationship between insulin and uric acid (UA) level in MS in adolescents

MATERIALS and METHODS: we studied 120 adolescence aged 10 to 19 in two groups: control group without metabolic syndrome and case group with metabolic syndrome. The Criteria of ATP III was considered as a diagnosis factor for metabolic syndrome.

DISCUSSION: Various studies have been conducted in various populations to evaluate the relationship between UA level and MS in adolescents. Abdominal obesity, low HDL, hypertriglyceridemia and hypertension are associated with high UA level. In their analysis, the MS OR in UA level≤4.9, 4.9-5.8 and≥5.8 mg/dl was 1, 2.53 and 9.03, respectively, which were higher than our findings in current study. Hyperinsulinemia caused by insulin resistance is one of the complications associated with MS, which puts individuals at risk of diabetes and cardiovascular events.

RESULTS: Uric acid level in the Case group was significantly higher than the control group (p = 0.0001, 43.8±1.4 vs. 4.1±1 mg/dl, respectively). Insulin level was significantly higher in the case group in compare to the control group (p = 0.008, 9.8±5.3 vs. 12.2±6 mU/ml, respectively).

CONCLUSION: The findings of this case-control study showed that adolescents with metabolic syndrome have a higher uric acid and insulin level in compare to normal subjects. We hypothesis that increase in serum insulin and uric acid level can be a risk factor in the development of metabolic syndrome.

Keywords metabolic syndrome      uric acid      insulin      adolescents     
Corresponding Authors: Forogh Nokhostin   
Online First Date: 13 September 2018    Issue Date: 30 November 2018
 Cite this article:   
Homeira Rashidi,Hajieh Shahbazian,Forogh Nokhostin, et al. The comparison of insulin and uric acid levels in adolescents with and without metabolic syndrome[J]. Front. Biol., 2018, 13(6): 452-457.
 URL:  
http://journal.hep.com.cn/fib/EN/10.1007/s11515-018-1515-1
http://journal.hep.com.cn/fib/EN/Y2018/V13/I6/452
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Homeira Rashidi
Hajieh Shahbazian
Forogh Nokhostin
Seyed Mahmood Latifi
Mehrian Jafarizade
Variables (2 × 120 n = ) group p
Healthy Patient
Age (year) 15.3±2.6 14.5±2.5 0.1
Systolic blood pressure (mm/Hg) 104.6±9.8 112.4±9.7 0.04
Diastolic blood pressure (mm/Hg) 64.2±9.9 67.8±9.7 0.04
Triglyceride (mg/dl) 74.4±17.9 179.6±73.3 0.3
Fasting blood glucose (mg/dl) 86.1±7.6 95.1±12.1 0.1
Waist circumference (cm) 65.1±6.9 80.1±13.6 0.01
Uric acid (mg/dl) 4.1±1 4.8±1.4 0.000
Body mass index (kg/m2) 19.2±3.3 22.9±8.7 0.00
Insulin level (mU/ml) 9.8±5.3 12.2±6 0.008
Tab.1  Comparison of variables in two groups
Uric acid level (mg/dl) 4.9≥ 5.8-4.9 ≥5.8
Group (n = 98) Healthy (n = 61) Patient (n = 13) Healthy (n = 27) Patient (n = 9) Healthy (n = 32) Patient
Age year 15.3±2.7 14.1±2.6 15.5±2.5 14.3±2.4 44±1.4 2.3±14.8
Systolic blood pressure mm/.Hg 104.68±10.41 111±10.5 105.4±8.3 114±10.4 102.5±4.6 112±9.04
Diastolic blood pressure mm/.Hg 64.5±10.1 67.04±9 63.3±10.7 67.6±10. 62.8±7.5 96.6±10.6
Triglyceride mg/dl 73.6±16.9 156.8±74.1 75.08±21.9 174.2±61.6 82.5±21.7 182.6±79.3
Fasting blood glucose mg/dl 86.45±7.6 96.47±12.8 82.6±4.8 93.2±10.5 86.5±10.1 11.8±94.1
Waist cm 64.6±6.8 74.49±12.7 65.8±6.5 84.9±13.3 68.2±7.4 86.7±10.8
Uric acid mg/dl 3.8±0.7 3.7±0.8 5.3±0.2 5.3±0.2 6.4±0.4 6.4±0.7
HDL mg/dl 63.4±13.1 44.9±8.2 56±6.7 47.4±10.6 18.7±1.7 21.9±5.7
Body mass index kg / m2 19.1±12.2 21.6±4.7 19.5±2.4 26.8±15.5 18.7±1.7 21.9±5.7
Tab.2  The distribution of metabolic indices in patients and healthy in three serum UA categories.
Uric acid level mg / dl 4.9≥ 5.8-4.9 p1 ≥5.8 p2 p-Trend
OR Metabolic syndrome 1 3.7(1.7-8.04) 0.001 5.9(2.4-14.35) 0.001 0.0001
Abdominal obesity 1 5.8(2.4-13.45) 0.001 11.01(4.1-29.3) 0.001 0.0001
High triglycerides 1 4.36 (2.01-9.47) 0.001 5.75(2.43-13.6) 0.001 0.0001
High blood pressure 1 1.8(0.8-4) 0.1 3.3(1.46-7.48) 0.004 0.001
Higher blood sugar 1 1.27(0.55-2.92) 0.5 1.68(0.74-3.84) 0.2 0.03
Low HDL 1 2.36(1.12-4.90) 0.02 2.15(0.98-4.7) 0.05 0.001
Tab.3  The odds ratio of MS and its indices in three categories of UA serum levels.
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