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Frontiers in Biology

Front Biol    2013, Vol. 8 Issue (1) : 1-31
DISC1 genetics, biology and psychiatric illness
Pippa A. THOMSON1, Elise L.V. MALAVASI1, Ellen GRüNEWALD1,2, Dinesh C. SOARES1, Malgorzata BORKOWSKA3, J. Kirsty MILLAR1()
1. The Centre for Molecular Medicine at the Medical Research Council Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK; 2. Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK; 3. Centre for Integrative Physiology, The University of Edinburgh, Edinburgh EH8 9XD, UK
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Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points toward DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon multiple critical pathways in the developing and adult brain.

Keywords DISC1      schizophrenia      depression      genetics      neural pathways     
Corresponding Author(s): MILLAR J. Kirsty,   
Issue Date: 01 February 2013
 Cite this article:   
Pippa A. THOMSON,Ellen GRüNEWALD,Dinesh C. SOARES, et al. DISC1 genetics, biology and psychiatric illness[J]. Front Biol, 2013, 8(1): 1-31.
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Dinesh C. SOARES
Malgorzata BORKOWSKA
J. Kirsty MILLAR
Fig.1  DISC1 in neurodevelopment, brain functioning and psychiatric illness. DISC1 is a scaffold protein with many functional partners associated with brain development and disease. : The DISC1 protein network was modified from String DB ( The t(1;11) Scottish pedigree was modified, with permission, from Blackwood et al. () . A fragment of the gene structure, SNPs and linkage disequilibrium blocks was generated using the UCSC genome browser ( : Examples of neurocognitive tests in which individuals carrying variants at the locus show altered performance; differences in brain activation by DISC1 L607F genotype as measured by functional MRI (with thanks to Andrew McIntosh); the P300 event related potential, which is elicited in decision making, and shows reduced amplitude and latency in DISC1 translocation carriers. : DISC1 is a multi-compartmentalised protein, present at the nucleus, centrosome, mitochondria, microtubules and synapse; DISC1 has roles in neurodevelopment and plasticity, in proliferation, migration and integration of neurons; neural stem cells are a promise in research and treatment of psychiatric and neurodegenerative disorders; GFP-labeled neural stem cells transplanted into the mouse brain can give rise to cells resembling normal hippocampal neurons (Image by Yirui Sun, Wellcome Images).
GenePresent in SZgeneNumber of studiesResultsMeta-analysis significant SNPs
BoldItalicY45 studies31 positive/9 negative/ 3 trendrs3737597, rs999710
AKT1Y17 studies9 positive/7 negative/1 trendrs3803300
ATF4Y1 studyNegative
ATF5Y1 studyNegative
CCDC141 (encodes
CCDC88A (encodes KIAA1212/Girdin)
CITY1 studyPositive
FEZ1Y5 studiesNegative
GSK3βY8 studies1 positive/6 negative/1 trend
KALRN(encodes KAL-7)
NDE1Y4 studiesnegative
NDEL1Y7 studies4 positive/3 negative
PAFAH1B1 (encodes LIS1)Y5 studies1 positive/4 negative
PCM1Y7 studies6 positive/1 negative
PCNTY3 studies1 positive/1 negative/1 trend
PDE4BY12 studies9 positive/3 negativers910694
PDE4DY2 studiesPositive
SLC12A2 (encodes NKCC1)
YWHAE(encodes 14-3-3?)Y5 studies2 positive/3 negative
Tab.1  Evidence of association to schizophrenia from candidate gene studies for selected DISC1 interactors
Alzheimer’s disease12044355IntronDISC19.00E-06
Neurotic disorders702543IntronPDE4D2.00E-06
Mental competency295973IntronPDE4D7.61E-07
Mental competency295973IntronPDE4D7.61E-07
Tab.2  Evidence of association between DISC1 interactors and brain-related traits
1 Abazyan B, Nomura J, Kannan G, Ishizuka K, Tamashiro K L, Nucifora F, Pogorelov V, Ladenheim B, Yang C, Krasnova I N, Cadet J L, Pardo C, Mori S, Kamiya A, Vogel M W, Sawa A, Ross C A, Pletnikov M V (2010). Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biol Psychiatry , 68(12): 1172–1181
doi: 10.1016/j.biopsych.2010.09.022 pmid:21130225
2 Alkhaja A K, Jans D C, Nikolov M, Vukotic M, Lytovchenko O, Ludewig F, Schliebs W, Riedel D, Urlaub H, Jakobs S, Deckers M (2012). MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Mol Biol Cell , 23(2): 247–257
doi: 10.1091/mbc.E11-09-0774 pmid:22114354
3 Alkuraya F S, Cai X, Emery C, Mochida G H, Al-Dosari M S, Felie J M, Hill R S, Barry B J, Partlow J N, Gascon G G, Kentab A, Jan M, Shaheen R, Feng Y, Walsh C A (2011). Human mutations in NDE1 cause extreme microcephaly with lissencephaly [corrected]. Am J Hum Genet , 88(5): 536–547 (corrected)
doi: 10.1016/j.ajhg.2011.04.003 pmid:21529751
4 Amador-Arjona A, Elliott J, Miller A, Ginbey A, Pazour G J, Enikolopov G, Roberts A J, Terskikh A V (2011). Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memory. J Neurosci , 31(27): 9933–9944
doi: 10.1523/JNEUROSCI.1062-11.2011 pmid:21734285
5 Ameri K, Harris A L (2008). Activating transcription factor 4. Int J Biochem Cell Biol , 40(1): 14–21
doi: 10.1016/j.biocel.2007.01.020 pmid:17466566
6 Ames A 3rd (2000). CNS energy metabolism as related to function. Brain Res Brain Res Rev , 34(1–2): 42–68
doi: 10.1016/S0165-0173(00)00038-2 pmid:11086186
7 An J, Shi J, He Q, Lui K, Liu Y, Huang Y, Sheikh M S (2012). CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology. J Biol Chem , 287(10): 7411–7426
doi: 10.1074/jbc.M111.277103 pmid:22228767
8 Andreasen N C, Wilcox M A, Ho B C, Epping E, Ziebell S, Zeien E, Weiss B, Wassink T (2011). Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes. Mol Psychiatry ,
doi: 10.1038/mp.2011.108
9 Atkin T A, Brandon N J, Kittler J T (2012). Disrupted in Schizophrenia 1 forms pathological aggresomes that disrupt its function in intracellular transport. Hum Mol Genet , 21(9): 2017–2028
doi: 10.1093/hmg/dds018 pmid:22291444
10 Atkin T A, Macaskill A F, Brandon N J, Kittler J T (2011). Disrupted in Schizophrenia-1 regulates intracellular trafficking of mitochondria in neurons. Mol Psychiatry , 16: 121–124
11 Austin C P, Ky B, Ma L, Morris J A, Shughrue P J (2004). Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development. Neuroscience , 124(1): 3–10
doi: 10.1016/j.neuroscience.2003.11.010 pmid:14960334
12 Ayalew M, Le-Niculescu H, Levey D F, Jain N, Changala B, Patel S D, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger J I, Corvin A, Geyer M, Tsuang M T, Salomon D, Schork N J, Fanous A H, O’Donovan M C, Niculescu A B (2012). Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. Mol Psychiatry , 17(9): 887–905
doi: 10.1038/mp.2012.37 pmid:22584867
13 Bakircioglu M, Carvalho O P, Khurshid M, Cox J J, Tuysuz B, Barak T, Yilmaz S, Caglayan O, Dincer A, Nicholas A K, Quarrell O, Springell K, Karbani G, Malik S, Gannon C, Sheridan E, Crosier M, Lisgo S N, Lindsay S, Bilguvar K, Gergely F, Gunel M, Woods C G (2011). The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis. Am J Hum Genet , 88(5): 523–535
doi: 10.1016/j.ajhg.2011.03.019 pmid:21529752
14 Bartsch D, Ghirardi M, Skehel P A, Karl K A, Herder S P, Chen M, Bailey C H, Kandel E R (1995). Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change. Cell , 83(6): 979–992
doi: 10.1016/0092-8674(95)90213-9 pmid:8521521
15 Beecham G W, Martin E R, Li Y J, Slifer M A, Gilbert J R, Haines J L, Pericak-Vance M A (2009). Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. Am J Hum Genet , 84(1): 35–43
doi: 10.1016/j.ajhg.2008.12.008 pmid:19118814
16 Berbari N F, O’Connor A K, Haycraft C J, Yoder B K (2009). The primary cilium as a complex signaling center. Curr Biol , 19(13): R526–R535
doi: 10.1016/j.cub.2009.05.025 pmid:19602418
17 Blackwood D H, Fordyce A, Walker M T, St Clair D M, Porteous D J, Muir W J (2001). Schizophrenia and affective disorders—cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet , 69(2): 428–433
doi: 10.1086/321969 pmid:11443544
18 Boxall R, Porteous D J, Thomson P A (2011). DISC1 and Huntington’s disease—overlapping pathways of vulnerability to neurological disorder? PLoS ONE , 6(1): e16263
doi: 10.1371/journal.pone.0016263 pmid:21298101
19 Bradshaw N J, Christie S, Soares D C, Carlyle B C, Porteous D J, Millar J K (2009). NDE1 and NDEL1: multimerisation, alternate splicing and DISC1 interaction. Neurosci Lett , 449(3): 228–233
doi: 10.1016/j.neulet.2008.10.095 pmid:19000741
20 Bradshaw N J, Ogawa F, Antolin-Fontes B, Chubb J E, Carlyle B C, Christie S, Claessens A, Porteous D J, Millar J K (2008). DISC1, PDE4B, and NDE1 at the centrosome and synapse. Biochem Biophys Res Commun , 377(4): 1091–1096
doi: 10.1016/j.bbrc.2008.10.120 pmid:18983980
21 Bradshaw N J, Soares D C, Carlyle B C, Ogawa F, Davidson-Smith H, Christie S, Mackie S, Thomson P A, Porteous D J, Millar J K (2011). PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1. J Neurosci , 31(24): 9043–9054
doi: 10.1523/JNEUROSCI.5410-10.2011 pmid:21677187
22 Brandon N J, Handford E J, Schurov I, Rain J C, Pelling M, Duran-Jimeniz B, Camargo L M, Oliver K R, Beher D, Shearman M S, Whiting P J (2004a). Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. Mol Cell Neurosci , 25(1): 42–55
doi: 10.1016/j.mcn.2003.09.009 pmid:14962739
23 Brandon N J, Handford E J, Schurov I, Rain J C, Pelling M, Duran-Jimeniz B, Camargo L M, Oliver K R, Beher D, Shearman M S, Whiting P J (2004b). Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. Mol Cell Neurosci , 25(1): 42–55
doi: 10.1016/j.mcn.2003.09.009 pmid:14962739
24 Brandon N J, Sawa A (2011). Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat Rev Neurosci , 12(12): 707–722
doi: 10.1038/nrn3120 pmid:22095064
25 Brauns S, Gollub R L, Roffman J L, Yendiki A, Ho B C, Wassink T H, Heinz A, Ehrlich S (2011). DISC1 is associated with cortical thickness and neural efficiency. Neuroimage , 57(4): 1591–1600
doi: 10.1016/j.neuroimage.2011.05.058 pmid:21642004
26 Breunig J J, Sarkisian M R, Arellano J I, Morozov Y M, Ayoub A E, Sojitra S, Wang B, Flavell R A, Rakic P, Town T (2008). Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proc Natl Acad Sci USA , 105(35): 13127–13132
doi: 10.1073/pnas.0804558105 pmid:18728187
27 Brown S M, Clapcote S J, Millar J K, Torrance H S, Anderson S M, Walker R, Rampino A, Roder J C, Thomson P A, Porteous D J, Evans K L (2011). Synaptic modulators Nrxn1 and Nrxn3 are disregulated in a Disc1 mouse model of schizophrenia. Mol Psychiatry , 16(6): 585–587
doi: 10.1038/mp.2010.134 pmid:21321563
28 Buizer-Voskamp J E, Muntjewerff J W, Strengman E, Sabatti C, Stefansson H, Vorstman J A, Ophoff R A, Genetic Risk and Outcome in Psychosis (GROUP) Consortium Members (2011). Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients. Biol Psychiatry , 70(7): 655–662
doi: 10.1016/j.biopsych.2011.02.015 pmid:21489405
29 Burdick K E, Kamiya A, Hodgkinson C A, Lencz T, DeRosse P, Ishizuka K, Elashvili S, Arai H, Goldman D, Sawa A, Malhotra A K (2008). Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Hum Mol Genet , 17(16): 2462–2473
doi: 10.1093/hmg/ddn146 pmid:18469341
30 Callicott J H, Straub R E, Pezawas L, Egan M F, Mattay V S, Hariri A R, Verchinski B A, Meyer-Lindenberg A, Balkissoon R, Kolachana B, Goldberg T E, Weinberger D R (2005). Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci USA , 102(24): 8627–8632
doi: 10.1073/pnas.0500515102 pmid:15939883
31 Camargo L M, Collura V, Rain J C, Mizuguchi K, Hermjakob H, Kerrien S, Bonnert T P, Whiting P J, Brandon N J (2007). Disrupted In Schizophrenia 1 interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol Psychiatry , 12(1): 74–86
doi: 10.1038/ pmid:17043677
32 Cannon T D, Hennah W, van Erp T G, Thompson P M, Lonnqvist J, Huttunen M, Gasperoni T, Tuulio-Henriksson A, Pirkola T, Toga A W, Kaprio J, Mazziotta J, Peltonen L (2005). Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Arch Gen Psychiatry , 62(11): 1205–1213
doi: 10.1001/archpsyc.62.11.1205 pmid:16275808
33 Carless M A, Glahn D C, Johnson M P, Curran J E, Bozaoglu K, Dyer T D, Winkler A M, Cole S A, Almasy L, Maccluer J W, Duggirala R, Moses E K, Goring H H, Blangero J (2011). Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes. Mol Psychiatry , 16: 1096–1104 , 1063
34 Carlisle H J, Luong T N, Medina-Marino A, Schenker L, Khorosheva E, Indersmitten T, Gunapala K M, Steele A D, O’Dell T J, Patterson P H, Kennedy M B (2011). Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction. J Neurosci , 31(45): 16194–16207
doi: 10.1523/JNEUROSCI.5877-10.2011 pmid:22072671
35 Carlyle B C, Mackie S, Christie S, Millar J K, Porteous D J (2011). Co-ordinated action of DISC1, PDE4B and GSK3β in modulation of cAMP signalling. Mol Psychiatry , 16(7): 693–694
doi: 10.1038/mp.2011.17 pmid:21358715
36 Chakirova G, Whalley H C, Thomson P A, Hennah W, Moorhead T W, Welch K A, Giles S, Hall J, Johnstone E C, Lawrie S M, Porteous D J, Brown V J, McIntosh A M (2011). The effects of DISC1 risk variants on brain activation in controls, patients with bipolar disorder and patients with schizophrenia. Psychiatry Res , 192(1): 20–28
doi: 10.1016/j.pscychresns.2011.01.015 pmid:21376542
37 Chakravarty M M, Felsky D, Tampakeras M, Lerch J P, Mulsant B H, Kennedy J L, Voineskos A N (2012). DISC1 and Striatal Volume: A potential risk phenotype for mental illness. Front Psychiatry , 3: 57
doi: 10.3389/fpsyt.2012.00057 pmid:22723785
38 Chen A, Muzzio I A, Malleret G, Bartsch D, Verbitsky M, Pavlidis P, Yonan A L, Vronskaya S, Grody M B, Cepeda I, Gilliam T C, Kandel E R (2003). Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins. Neuron , 39(4): 655–669
doi: 10.1016/S0896-6273(03)00501-4 pmid:12925279
39 Chen S Y, Huang P H, Cheng H J (2011). Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling. Proc Natl Acad Sci USA , 108(14): 5861–5866
doi: 10.1073/pnas.1018128108 pmid:21422296
40 Chiang C H, Su Y, Wen Z, Yoritomo N, Ross C A, Margolis R L, Song H, Ming G L (2011). Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation. Mol Psychiatry , 16(4): 358–360
doi: 10.1038/mp.2011.13 pmid:21339753
41 Chiba S, Hashimoto R, Hattori S, Yohda M, Lipska B, Weinberger D R, Kunugi H (2006). Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus. J Neural Transm , 113(9): 1337–1346
doi: 10.1007/s00702-005-0414-1 pmid:16463116
42 Chubb J E, Bradshaw N J, Soares D C, Porteous D J, Millar J K (2008). The DISC locus in psychiatric illness. Mol Psychiatry , 13(1): 36–64
doi: 10.1038/ pmid:17912248
43 Clapcote S J, Lipina T V, Millar J K, Mackie S, Christie S, Ogawa F, Lerch J P, Trimble K, Uchiyama M, Sakuraba Y, Kaneda H, Shiroishi T, Houslay M D, Henkelman R M, Sled J G, Gondo Y, Porteous D J, Roder J C (2007). Behavioral phenotypes of Disc1 missense mutations in mice. Neuron , 54(3): 387–402
doi: 10.1016/j.neuron.2007.04.015 pmid:17481393
44 Clay H B, Sillivan S, Konradi C (2011). Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia. Int J Dev Neurosci , 29(3): 311–324
doi: 10.1016/j.ijdevneu.2010.08.007 pmid:20833242
45 Collins D M, Murdoch H, Dunlop A J, Charych E, Baillie G S, Wang Q, Herberg F W, Brandon N, Prinz A, Houslay M D (2008). Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA). Cell Signal , 20(12): 2356–2369
doi: 10.1016/j.cellsig.2008.09.017 pmid:18845247
46 Costa-Mattioli M, Gobert D, Stern E, Gamache K, Colina R, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjevi? K, Lacaille J C, Nader K, Sonenberg N (2007). eIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell , 129(1): 195–206
doi: 10.1016/j.cell.2007.01.050 pmid:17418795
47 Costa-Mattioli M, Sonenberg N (2006). Translational control of long-term synaptic plasticity and memory storage by eIF2α. Crit Rev Neurobiol , 18(1–2): 187–195
doi: 10.1615/CritRevNeurobiol.v18.i1-2.190 pmid:17725521
48 Crabbe J C, Wahlsten D, Dudek B C (1999). Genetics of mouse behavior: interactions with laboratory environment. Science , 284(5420): 1670–1672
doi: 10.1126/science.284.5420.1670 pmid:10356397
49 Crepel A, Breckpot J, Fryns J P, De la Marche W, Steyaert J, Devriendt K, Peeters H (2010). DISC1 duplication in two brothers with autism and mild mental retardation. Clin Genet , 77(4): 389–394
doi: 10.1111/j.1399-0004.2009.01318.x pmid:20002455
50 Crowley J J, Hilliard C E, Kim Y, Morgan M B, Lewis L R, Muzny D M, Hawes A C, Sabo A, Wheeler D A, Lieberman J A, Sullivan P F, Gibbs R A (2012). Deep resequencing and association analysis of schizophrenia candidate genes. Mol Psychiatry .
doi: 10.1038/mp.2012.28
51 da Silva Alves F, Figee M, van Avamelsvoort T, Veltman D, de Haan L (2008). The revised dopamine hypothesis of schizophrenia: evidence from pharmacological MRI studies with atypical antipsychotic medication. Psychopharmacol Bull , 41(1): 121–132
52 Dammermann A, Merdes A (2002). Assembly of centrosomal proteins and microtubule organization depends on PCM-1. J Cell Biol , 159(2): 255–266
doi: 10.1083/jcb.200204023 pmid:12403812
53 De Rienzo G, Bishop J A, Mao Y, Pan L, Ma T P, Moens C B, Tsai L H, Sive H (2011). Disc1 regulates both β-catenin-mediated and noncanonical Wnt signaling during vertebrate embryogenesis. FASEB J , 25(12): 4184–4197
doi: 10.1096/fj.11-186239 pmid:21859895
54 Debono R, Topless R, Markie D, Black M A, Merriman T R (2012). Analysis of the DISC1 translocation partner (11q14.3) in genetic risk of schizophrenia. Genes Brain Behav , 11(7): 859–863
55 Di Giorgio A, Blasi G, Sambataro F, Rampino A, Papazacharias A, Gambi F, Romano R, Caforio G, Rizzo M, Latorre V, Popolizio T, Kolachana B, Callicott J H, Nardini M, Weinberger D R, Bertolino A (2008). Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding. Eur J Neurosci , 28(10): 2129–2136
doi: 10.1111/j.1460-9568.2008.06482.x pmid:19046394
56 Domire J S, Green J A, Lee K G, Johnson A D, Askwith C C, Mykytyn K (2011). Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins. Cell Mol Life Sci , 68(17): 2951–2960
doi: 10.1007/s00018-010-0603-4 pmid:21152952
57 Drerup C M, Wiora H M, Topczewski J, Morris J A (2009). Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation. Development , 136(15): 2623–2632
doi: 10.1242/dev.030577 pmid:19570850
58 Duan X, Chang J H, Ge S, Faulkner R L, Kim J Y, Kitabatake Y, Liu X B, Yang C H, Jordan J D, Ma D K, Liu C Y, Ganesan S, Cheng H J, Ming G L, Lu B, Song H (2007). Disrupted In Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell , 130(6): 1146–1158
doi: 10.1016/j.cell.2007.07.010 pmid:17825401
59 Eastwood S L, Hodgkinson C A, Harrison P J (2009). DISC-1 Leu607Phe alleles differentially affect centrosomal PCM1 localization and neurotransmitter release. Mol Psychiatry , 14(6): 556–557
doi: 10.1038/mp.2009.13 pmid:19455170
60 Eastwood S L, Walker M, Hyde T M, Kleinman J E, Harrison P J (2010). The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain. Hum Mol Genet , 19(12): 2487–2496
doi: 10.1093/hmg/ddq130 pmid:20360304
61 Enomoto A (2011). Roles of DISC1-interacting protein Girdin in postnatal development and adult neurogenesis in the dentate gyrus. Nihon Shinkei Seishin Yakurigaku Zasshi , 31(1): 23–28
62 Eykelenboom J E, Briggs G J, Bradshaw N J, Soares D C, Ogawa F, Christie S, Malavasi E L, Makedonopoulou P, Mackie S, Malloy M P, Wear M A, Blackburn E A, Bramham J, McIntosh A M, Blackwood D H, Muir W J, Porteous D J, Millar J K (2012). A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins. Hum Mol Genet , 21(15): 3374–3386
doi: 10.1093/hmg/dds169 pmid:22547224
63 Faulkner R L, Jang M H, Liu X B, Duan X, Sailor K A, Kim J Y, Ge S, Jones E G, Ming G L, Song H, Cheng H J (2008). Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain. Proc Natl Acad Sci USA , 105(37): 14157–14162
doi: 10.1073/pnas.0806658105 pmid:18780780
64 Feng Y, Walsh C A (2004). Mitotic spindle regulation by Nde1 controls cerebral cortical size. Neuron , 44(2): 279–293
doi: 10.1016/j.neuron.2004.09.023 pmid:15473967
65 Filges I, R?thlisberger B, Boesch N, Weber P, Wenzel F, Huber A R, Heinimann K, Miny P (2010). Interstitial deletion 1q42 in a patient with agenesis of corpus callosum: Phenotype-genotype comparison to the 1q41q42 microdeletion suggests a contiguous 1q4 syndrome. Am J Med Genet A , 152A(4): 987–993
doi: 10.1002/ajmg.a.33330 pmid:20358614
66 Flores R 3rd, Hirota Y, Armstrong B, Sawa A, Tomoda T (2011). DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway. Neurosci Res , 71(1): 71–77
doi: 10.1016/j.neures.2011.05.014 pmid:21664390
67 Frank C L, Ge X, Xie Z, Zhou Y, Tsai L H (2010). Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. J Biol Chem , 285(43): 33324–33337
doi: 10.1074/jbc.M110.140699 pmid:20724472
68 Fujita T, Maturana A D, Ikuta J, Hamada J, Walchli S, Suzuki T, Sawa H, Wooten M W, Okajima T, Tatematsu K, Tanizawa K, Kuroda S (2007). Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells. Biochem Biophys Res Commun , 361(3): 605–610
doi: 10.1016/j.bbrc.2007.07.050 pmid:17669366
69 Fukuda T, Sugita S, Inatome R, Yanagi S (2010). CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. J Biol Chem , 285(52): 40554–40561
doi: 10.1074/jbc.M110.179481 pmid:20956536
70 Gasperoni T L, Ekelund J, Huttunen M, Palmer C G, Tuulio-Henriksson A, L?nnqvist J, Kaprio J, Peltonen L, Cannon T D (2003). Genetic linkage and association between chromosome 1q and working memory function in schizophrenia. Am J Med Genet B Neuropsychiatr Genet , 116B(1): 8–16
doi: 10.1002/ajmg.b.10757 pmid:12497606
71 Gentile M, Di Carlo A, Volpe P, Pansini A, Nanna P, Valenzano M C, Buonadonna A L (2003). FISH and cytogenetic characterization of a terminal chromosome 1q deletion: clinical case report and phenotypic implications. Am J Med Genet A , 117A(3): 251–254
doi: 10.1002/ajmg.a.10018 pmid:12599188
72 Gershon E S, Alliey-Rodriguez N, Liu C (2011). After GWAS: searching for genetic risk for schizophrenia and bipolar disorder. Am J Psychiatry , 168(3): 253–256
doi: 10.1176/appi.ajp.2010.10091340 pmid:21285144
73 Green E K, Grozeva D, Sims R, Raybould R, Forty L, Gordon-Smith K, Russell E, St Clair D, Young A H, Ferrier I N, Kirov G, Jones I, Jones L, Owen M J, O’Donovan M C, Craddock N (2011). DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls. Am J Med Genet B Neuropsychiatr Genet , 156B(4): 490–492
doi: 10.1002/ajmg.b.31187 pmid:21445958
74 Green E K, Norton N, Peirce T, Grozeva D, Kirov G, Owen M J, O’Donovan M C, Craddock N (2006). Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation. Mol Psychiatry , 11(9): 798–799
doi: 10.1038/ pmid:16936759
75 Green T A, Alibhai I N, Unterberg S, Neve R L, Ghose S, Tamminga C A, Nestler E J (2008). Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior. J Neurosci , 28(9): 2025–2032
doi: 10.1523/JNEUROSCI.5273-07.2008 pmid:18305237
76 Greene L A, Lee H Y, Angelastro J M (2009). The transcription factor ATF5: role in neurodevelopment and neural tumors. J Neurochem , 108(1): 11–22
doi: 10.1111/j.1471-4159.2008.05749.x pmid:19046351
77 Guven A, Gunduz A, Bozoglu T M, Yalcinkaya C, Tolun A (2012). Novel NDE1 homozygous mutation resulting in microhydranencephaly and not microlyssencephaly. Neurogenetics , 13(3): 189–194
doi: 10.1007/s10048-012-0326-9 pmid:22526350
78 Han X J, Tomizawa K, Fujimura A, Ohmori I, Nishiki T, Matsushita M, Matsui H (2011). Regulation of mitochondrial dynamics and neurodegenerative diseases. Acta Med Okayama , 65(1): 1–10
79 Han Y G, Spassky N, Romaguera-Ros M, Garcia-Verdugo J M, Aguilar A, Schneider-Maunoury S, Alvarez-Buylla A (2008). Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat Neurosci , 11(3): 277–284
doi: 10.1038/nn2059 pmid:18297065
80 H?ndel M, Schulz S, Stanarius A, Schreff M, Erdtmann-Vourliotis M, Schmidt H, Wolf G, H?llt V (1999). Selective targeting of somatostatin receptor 3 to neuronal cilia. Neuroscience , 89(3): 909–926
doi: 10.1016/S0306-4522(98)00354-6 pmid:10199624
81 Hanson N D, Owens M J, Nemeroff C B (2011). Depression, antidepressants, and neurogenesis: a critical reappraisal. Neuropsychopharmacology , 36(13): 2589–2602
doi: 10.1038/npp.2011.220 pmid:21937982
82 Haque F N, Lipina T V, Roder J C, Wong A H (2012). Social defeat interacts with Disc1 mutations in the mouse to affect behavior. Behav Brain Res , 233(2): 337–344
doi: 10.1016/j.bbr.2012.05.037 pmid:22659396
83 Harris S E, Hennah W, Thomson P A, Luciano M, Starr J M, Porteous D J, Deary I J (2010). Variation in DISC1 is associated with anxiety, depression and emotional stability in elderly women. Mol Psychiatry , 15(3): 232–234
doi: 10.1038/mp.2009.88 pmid:20168324
84 Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger D R, Sawa A, Kunugi H (2006). Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet , 15(20): 3024–3033
doi: 10.1093/hmg/ddl244 pmid:16959794
85 Hayashi-Takagi A, Takaki M, Graziane N, Seshadri S, Murdoch H, Dunlop A J, Makino Y, Seshadri A J, Ishizuka K, Srivastava D P, Xie Z, Baraban J M, Houslay M D, Tomoda T, Brandon N J, Kamiya A, Yan Z, Penzes P, Sawa A (2010). Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nat Neurosci , 13(3): 327–332
doi: 10.1038/nn.2487 pmid:20139976
86 Hennah W, Porteous D (2009). The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes. PLoS ONE , 4(3): e4906
doi: 10.1371/journal.pone.0004906 pmid:19300510
87 Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, Anjorin A, Blackwood D, Curtis D, Deary I J, Harris S E, Isomets? E T, Lawrence J, L?nnqvist J, Muir W, Palotie A, Partonen T, Paunio T, Pylkk? E, Robinson M, Soronen P, Suominen K, Suvisaari J, Thirumalai S, St Clair D, Gurling H, Peltonen L, Porteous D (2009). DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Mol Psychiatry , 14(9): 865–873
doi: 10.1038/mp.2008.22 pmid:18317464
88 Hennah W, Tomppo L, Hiekkalinna T, Palo O M, Kilpinen H, Ekelund J, Tuulio-Henriksson A, Silander K, Partonen T, Paunio T, Terwilliger J D, L?nnqvist J, Peltonen L (2007). Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1. Hum Mol Genet , 16(5): 453–462
doi: 10.1093/hmg/ddl462 pmid:17185386
89 Higginbotham H R, Gleeson J G (2007). The centrosome in neuronal development. Trends Neurosci , 30(6): 276–283
doi: 10.1016/j.tins.2007.04.001 pmid:17420058
90 Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, Wu D, Xue R, Andradé M, Tankou S, Mori S, Gallagher M, Ishizuka K, Pletnikov M, Kida S, Sawa A (2007). Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci USA , 104(36): 14501–14506
doi: 10.1073/pnas.0704774104 pmid:17675407
91 Hildebrandt F, Benzing T, Katsanis N (2011). Ciliopathies. N Engl J Med , 364(16): 1533–1543
doi: 10.1056/NEJMra1010172 pmid:21506742
92 Honda A, Miyoshi K, Baba K, Taniguchi M, Koyama Y, Kuroda S, Katayama T, Tohyama M (2004). Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain. Brain Res Mol Brain Res , 122(1): 89–92
doi: 10.1016/j.molbrainres.2003.11.020 pmid:14992819
93 Hoppins S, Collins S R, Cassidy-Stone A, Hummel E, Devay R M, Lackner L L, Westermann B, Schuldiner M, Weissman J S, Nunnari J (2011). A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol , 195(2): 323–340
doi: 10.1083/jcb.201107053 pmid:21987634
94 Hotta Y, Ohnuma T, Hanzawa R, Shibata N, Maeshima H, Baba H, Hatano T, Takebayashi Y, Kitazawa M, Higa M, Suzuki T, Arai H (2011). Association study between Disrupted-in-Schizophrenia-1 (DISC1) and Japanese patients with treatment-resistant schizophrenia (TRS). Prog Neuropsychopharmacol Biol Psychiatry , 35(2): 636–639
doi: 10.1016/j.pnpbp.2011.01.011 pmid:21256178
95 Houlihan L M, Harris S E, Luciano M, Gow A J, Starr J M, Visscher P M, Deary I J (2009). Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936. Genes Brain Behav , 8(2): 238–247
doi: 10.1111/j.1601-183X.2008.00470.x pmid:19077115
96 Houslay M D, Adams D R (2003). PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. Biochem J , 370(Pt 1): 1–18
doi: 10.1042/BJ20021698 pmid:12444918
97 Ibi D, Nagai T, Koike H, Kitahara Y, Mizoguchi H, Niwa M, Jaaro-Peled H, Nitta A, Yoneda Y, Nabeshima T, Sawa A, Yamada K (2010). Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. Behav Brain Res , 206(1): 32–37
doi: 10.1016/j.bbr.2009.08.027 pmid:19716847
98 Igarashi T, Izumi H, Uchiumi T, Nishio K, Arao T, Tanabe M, Uramoto H, Sugio K, Yasumoto K, Sasaguri Y, Wang K Y, Otsuji Y, Kohno K (2007). Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines. Oncogene , 26(33): 4749–4760
doi: 10.1038/sj.onc.1210289 pmid:17297441
99 Ikuta J, Maturana A, Fujita T, Okajima T, Tatematsu K, Tanizawa K, Kuroda S (2007). Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility. Biochem Biophys Res Commun , 353(1): 127–132
doi: 10.1016/j.bbrc.2006.11.142 pmid:17173861
100 Ingason A, Rujescu D, Cichon S, Sigurdsson E, Sigmundsson T, Pietil?inen OP, Buizer-Voskamp JE, Strengman E, Francks C, Muglia P, Gylfason A, Gustafsson O, Olason P I, Steinberg S, Hansen T, Jakobsen K D, Rasmussen H B, Giegling I, M?ller H J, Hartmann A, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Bramon E, Kiemeney L A, Franke B, Murray R, Vassos E, Toulopoulou T, Mühleisen T W, Tosato S, Ruggeri M, Djurovic S, Andreassen O A, Zhang Z, Werge T, Ophoff R A, Rietschel M, N?then M M, Petursson H, Stefansson H, Peltonen L, Collier D, Stefansson K, St Clair D M, GROUP Investigators (2011). Copy number variations of chromosome 16p13.1 region associated with schizophrenia. Mol Psychiatry , 16(1): 17–25
doi: 10.1038/mp.2009.101 pmid:19786961
101 Ishizuka K, Kamiya A, Oh E C, Kanki H, Seshadri S, Robinson J F, Murdoch H, Dunlop A J, Kubo K, Furukori K, Huang B, Zeledon M, Hayashi-Takagi A, Okano H, Nakajima K, Houslay M D, Katsanis N, Sawa A (2011). DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. Nature , 473(7345): 92–96
doi: 10.1038/nature09859 pmid:21471969
102 James R, Adams R R, Christie S, Buchanan S R, Porteous D J, Millar J K (2004). Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria. Mol Cell Neurosci , 26(1): 112–122
doi: 10.1016/j.mcn.2004.01.013 pmid:15121183
103 Jepsen K, Rosenfeld M G (2002). Biological roles and mechanistic actions of co-repressor complexes. J Cell Sci , 115(Pt 4): 689–698
104 Jia P, Wang L, Fanous A H, Pato C N, Edwards T L, Zhao Z, the International Schizophrenia Consortium (2012). Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia. PLOS Comput Biol , 8(7): e1002587
doi: 10.1371/journal.pcbi.1002587 pmid:22792057
105 John G B, Shang Y, Li L, Renken C, Mannella C A, Selker J M, Rangell L, Bennett M J, Zha J (2005). The mitochondrial inner membrane protein mitofilin controls cristae morphology. Mol Biol Cell , 16(3): 1543–1554
doi: 10.1091/mbc.E04-08-0697 pmid:15647377
106 K?hler A K, Rimol L M, Brown A A, Djurovic S, Hartberg C B, Melle I, Dale A M, Andreassen O A, Agartz I (2012). Effect of DISC1 SNPs on brain structure in healthy controls and patients with a history of psychosis. Am J Med Genet B Neuropsychiatr Genet , 159B(6): 722–730
doi: 10.1002/ajmg.b.32076 pmid:22815203
107 Kamiya A, Kubo K, Tomoda T, Takaki M, Youn R, Ozeki Y, Sawamura N, Park U, Kudo C, Okawa M, Ross C A, Hatten M E, Nakajima K, Sawa A (2005). A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat Cell Biol , 7(12): 1167–1178
doi: 10.1038/ncb1328 pmid:16299498
108 Kamiya A, Tan P L, Kubo K, Engelhard C, Ishizuka K, Kubo A, Tsukita S, Pulver A E, Nakajima K, Cascella N G, Katsanis N, Sawa A (2008). Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. Arch Gen Psychiatry , 65(9): 996–1006
doi: 10.1001/archpsyc.65.9.996 pmid:18762586
109 Kang E, Burdick K E, Kim J Y, Duan X, Guo J U, Sailor K A, Jung D E, Ganesan S, Choi S, Pradhan D, Lu B, Avramopoulos D, Christian K, Malhotra A K, Song H, Ming G L (2011). Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron , 72(4): 559–571
doi: 10.1016/j.neuron.2011.09.032 pmid:22099459
110 Karpinski B A, Morle G D, Huggenvik J, Uhler M D, Leiden J M (1992). Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. Proc Natl Acad Sci USA , 89(11): 4820–4824
doi: 10.1073/pnas.89.11.4820 pmid:1534408
111 Katsel P, Tan W, Abazyan B, Davis K L, Ross C, Pletnikov M V, Haroutunian V (2011). Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes. Schizophr Res , 130(1–3): 238–249
doi: 10.1016/j.schres.2011.04.021 pmid:21605958
112 Kim J Y, Duan X, Liu C Y, Jang M H, Guo J U, Pow-anpongkul N, Kang E, Song H, Ming G L (2009). DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron , 63(6): 761–773
doi: 10.1016/j.neuron.2009.08.008 pmid:19778506
113 Kim J Y, Liu C Y, Zhang F, Duan X, Wen Z, Song J, Feighery E, Lu B, Rujescu D, St Clair D, Christian K, Callicott J H, Weinberger D R, Song H, Ming G L (2012). Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia. Cell , 148(5): 1051–1064
doi: 10.1016/j.cell.2011.12.037 pmid:22385968
114 Kim S, Zaghloul N A, Bubenshchikova E, Oh E C, Rankin S, Katsanis N, Obara T, Tsiokas L (2011). Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. Nat Cell Biol , 13(4): 351–360
doi: 10.1038/ncb2183 pmid:21394081
115 Kirkpatrick B, Xu L, Cascella N, Ozeki Y, Sawa A, Roberts R C (2006). DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex. J Comp Neurol , 497(3): 436–450
doi: 10.1002/cne.21007 pmid:16736468
116 Koike H, Arguello P A, Kvajo M, Karayiorgou M, Gogos J A (2006). Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci USA , 103(10): 3693–3697
doi: 10.1073/pnas.0511189103 pmid:16484369
117 Korth C (2009). DISCopathies: brain disorders related to DISC1 dysfunction. Rev Neurosci , 20(5–6): 321–330
doi: 10.1515/REVNEURO.2009.20.5-6.321 pmid:20397618
118 Korth C (2012). Aggregated proteins in schizophrenia and other chronic mental diseases: DISC1opathies. Prion , 6(2): 134–141
doi: 10.4161/pri.18989 pmid:22421208
119 Koyanagi S, Hamdan A M, Horiguchi M, Kusunose N, Okamoto A, Matsunaga N, Ohdo S (2011). cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. J Biol Chem , 286(37): 32416–32423
doi: 10.1074/jbc.M111.258970 pmid:21768648
120 Kriegstein A R, Noctor S C (2004). Patterns of neuronal migration in the embryonic cortex. Trends Neurosci , 27(7): 392–399
doi: 10.1016/j.tins.2004.05.001 pmid:15219738
121 Kristiansen L V, Huerta I, Beneyto M, Meador-Woodruff J H (2007). NMDA receptors and schizophrenia. Curr Opin Pharmacol , 7(1): 48–55
doi: 10.1016/j.coph.2006.08.013 pmid:17097347
122 Kubo K, Tomita K, Uto A, Kuroda K, Seshadri S, Cohen J, Kaibuchi K, Kamiya A, Nakajima K (2010). Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi. Biochem Biophys Res Commun , 400(4): 631–637
doi: 10.1016/j.bbrc.2010.08.117 pmid:20807500
123 Kuijpers M, Hoogenraad C C (2011). Centrosomes, microtubules and neuronal development. Mol Cell Neurosci , 48(4): 349–358
doi: 10.1016/j.mcn.2011.05.004 pmid:21722732
124 Kumamoto N, Gu Y, Wang J, Janoschka S, Takemaru K, Levine J, Ge S (2012). A role for primary cilia in glutamatergic synaptic integration of adult-born neurons. Nat Neurosci , 15: 399–405, S391
125 Kuroda K, Yamada S, Tanaka M, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K, Kaibuchi K (2011). Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet , 20(23): 4666–4683
doi: 10.1093/hmg/ddr400 pmid:21903668
126 Kvajo M, McKellar H, Arguello P A, Drew L J, Moore H, MacDermott A B, Karayiorgou M, Gogos J A (2008). A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition. Proc Natl Acad Sci USA , 105(19): 7076–7081
doi: 10.1073/pnas.0802615105 pmid:18458327
127 Kvajo M, McKellar H, Drew L J, Lepagnol-Bestel A M, Xiao L, Levy R J, Blazeski R, Arguello P A, Lacefield C O, Mason C A, Simonneau M, O’Donnell J M, MacDermott A B, Karayiorgou M, Gogos J A (2011). Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice. Proc Natl Acad Sci USA , 108(49): E1349–E1358
doi: 10.1073/pnas.1114113108 pmid:22049344
128 Lam C, Vergnolle M A, Thorpe L, Woodman P G, Allan V J (2010). Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning. J Cell Sci , 123(Pt 2): 202–212
doi: 10.1242/jcs.059337 pmid:20048338
129 Landers J E, Melki J, Meininger V, Glass J D, van den Berg L H, van Es M A, Sapp P C, van Vught P W, McKenna-Yasek D M, Blauw H M, Cho T J, Polak M, Shi L, Wills A M, Broom W J, Ticozzi N, Silani V, Ozoguz A, Rodriguez-Leyva I, Veldink J H, Ivinson A J, Saris C G, Hosler B A, Barnes-Nessa A, Couture N, Wokke J H, Kwiatkowski T J Jr, Ophoff R A, Cronin S, Hardiman O, Diekstra F P, Leigh P N, Shaw C E, Simpson C L, Hansen V K, Powell J F, Corcia P, Salachas F, Heath S, Galan P, Georges F, Horvitz H R, Lathrop M, Purcell S, Al-Chalabi A, Brown R H Jr (2009). Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci USA , 106(22): 9004–9009
doi: 10.1073/pnas.0812937106 pmid:19451621
130 Le-Niculescu H, Patel S D, Bhat M, Kuczenski R, Faraone S V, Tsuang M T, McMahon F J, Schork N J, Nurnberger J I Jr, Niculescu A B 3rd (2009). Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms. Am J Med Genet B Neuropsychiatr Genet , 150B(2): 155–181
doi: 10.1002/ajmg.b.30887 pmid:19025758
131 Lee F H, Fadel M P, Preston-Maher K, Cordes S P, Clapcote S J, Price D J, Roder J C, Wong A H (2011). Disc1 point mutations in mice affect development of the cerebral cortex. J Neurosci , 31(9): 3197–3206
doi: 10.1523/JNEUROSCI.4219-10.2011 pmid:21368031
132 Lee J A, Kim H, Lee Y S, Kaang B K (2003). Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein-2, a repressor of long-term facilitation, in Aplysia kurodai sensory-to-motor synapses. Neurosci Lett , 337(1): 9–12
doi: 10.1016/S0304-3940(02)01285-5 pmid:12524159
133 Lee M M, Reif A, Schmitt A G (2012). Major depression: A role for hippocampal neurogenesis? Curr Top Behav Neurosci ,
doi: 10.1007/7854_2012_226
134 Leliveld S R, Bader V, Hendriks P, Prikulis I, Sajnani G, Requena J R, Korth C (2008). Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease. J Neurosci , 28(15): 3839–3845
doi: 10.1523/JNEUROSCI.5389-07.2008 pmid:18400883
135 Leliveld S R, Hendriks P, Michel M, Sajnani G, Bader V, Trossbach S, Prikulis I, Hartmann R, Jonas E, Willbold D, Requena J R, Korth C (2009). Oligomer assembly of the C-terminal DISC1 domain (640-854) is controlled by self-association motifs and disease-associated polymorphism S704C. Biochemistry , 48(32): 7746–7755
doi: 10.1021/bi900901e pmid:19583211
136 Lemos D R, Goodspeed L, Tonelli L, Antoch M P, Ojeda S R, Urbanski H F (2007). Evidence for circadian regulation of activating transcription factor 5 but not tyrosine hydroxylase by the chromaffin cell clock. Endocrinology , 148(12): 5811–5821
doi: 10.1210/en.2007-0610 pmid:17823250
137 Li W, Zhou Y, Jentsch J D, Brown R A, Tian X, Ehninger D, Hennah W, Peltonen L, L?nnqvist J, Huttunen M O, Kaprio J, Trachtenberg J T, Silva A J, Cannon T D (2007). Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci USA , 104(46): 18280–18285
doi: 10.1073/pnas.0706900104 pmid:17984054
138 Li Y, Liu B, Hou B, Qin W, Wang D, Yu C, Jiang T (2012). Less efficient information transfer in Cys-allele carriers of DISC1: A brain network study based on diffusion MRI. Cereb Cortex ,
doi: 10.1093/cercor/bhs1
139 Lipina T V, Kaidanovich-Beilin O, Patel S, Wang M, Clapcote S J, Liu F, Woodgett J R, Roder J C (2011). Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3. Synapse , 65(3): 234–248
doi: 10.1002/syn.20839 pmid:20687111
140 Lipina T V, Niwa M, Jaaro-Peled H, Fletcher P J, Seeman P, Sawa A, Roder J C (2010). Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia. Genes Brain Behav , 9(7): 777–789
doi: 10.1111/j.1601-183X.2010.00615.x pmid:20618446
141 Lipina T V, Wang M, Liu F, Roder J C (2012). Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice. Neuropharmacology , 62(3): 1252–1262
doi: 10.1016/j.neuropharm.2011.02.020 pmid:21376063
142 Lopez A D, Murray C C (1998). The global burden of disease, 1990-2020. Nat Med , 4(11): 1241–1243
doi: 10.1038/3218 pmid:9809543
143 Louvi A, Grove E A (2011). Cilia in the CNS: the quiet organelle claims center stage. Neuron , 69(6): 1046–1060
doi: 10.1016/j.neuron.2011.03.002 pmid:21435552
144 Ma L, Liu Y, Ky B, Shughrue P J, Austin C P, Morris J A (2002). Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics , 80(6): 662–672
doi: 10.1006/geno.2002.7012 pmid:12504857
145 Ma T M, Abazyan S, Abazyan B, Nomura J, Yang C, Seshadri S, Sawa A, Snyder S H, Pletnikov M V (2012). Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. Mol Psychiatry .
doi: 10.1038/mp.2012.97
146 Maeda K, Nwulia E, Chang J, Balkissoon R, Ishizuka K, Chen H, Zandi P, McInnis M G, Sawa A (2006). Differential expression of disrupted-in-schizophrenia (DISC1) in bipolar disorder. Biol Psychiatry , 60(9): 929–935
doi: 10.1016/j.biopsych.2006.03.032 pmid:16814263
147 Maher B J, LoTurco J J (2012). Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses. PLoS ONE , 7(3): e34053
doi: 10.1371/journal.pone.0034053 pmid:22479520
148 Malavasi E L, Ogawa F, Porteous D J, Millar J K (2012). DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription. Hum Mol Genet , 21(12): 2779–2792
doi: 10.1093/hmg/dds106 pmid:22422769
149 Mao Y, Ge X, Frank C L, Madison J M, Koehler A N, Doud M K, Tassa C, Berry E M, Soda T, Singh K K, Biechele T, Petryshen T L, Moon R T, Haggarty S J, Tsai L H (2009). Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell , 136(6): 1017–1031
doi: 10.1016/j.cell.2008.12.044 pmid:19303846
150 Marley A, von Zastrow M (2010). DISC1 regulates primary cilia that display specific dopamine receptors. PLoS ONE , 5(5): e10902
doi: 10.1371/journal.pone.0010902 pmid:20531939
151 Mata I, Perez-Iglesias R, Roiz-Santia?ez R, Tordesillas-Gutierrez D, Gonzalez-Mandly A, Berja A, Vazquez-Barquero J L, Crespo-Facorro B (2010). Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia. Neuroimage , 53(3): 1016–1022
doi: 10.1016/j.neuroimage.2009.11.010 pmid:19913623
152 Mathieson I, Munafò M R, Flint J (2012). Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia. Mol Psychiatry , 17(6): 634–641
doi: 10.1038/mp.2011.41 pmid:21483435
153 McEvoy J P (2007). The costs of schizophrenia. J Clin Psychiatry , 68(Suppl 14): 4–7
154 Meyer K D, Morris J A (2009). Disc1 regulates granule cell migration in the developing hippocampus. Hum Mol Genet , 18(17): 3286–3297
doi: 10.1093/hmg/ddp266 pmid:19502360
155 Meyer-Lindenberg A, Weinberger D R (2006). Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci , 7(10): 818–827
doi: 10.1038/nrn1993 pmid:16988657
156 Millar J K, Christie S, Porteous D J (2003). Yeast two-hybrid screens implicate DISC1 in brain development and function. Biochem Biophys Res Commun , 311(4): 1019–1025
doi: 10.1016/j.bbrc.2003.10.101 pmid:14623284
157 Millar J K, Christie S, Semple C A, Porteous D J (2000a). Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia. Genomics , 67(1): 69–77
doi: 10.1006/geno.2000.6239 pmid:10945471
158 Millar J K, James R, Christie S, Porteous D J (2005a). Disrupted in schizophrenia 1 (DISC1): subcellular targeting and induction of ring mitochondria. Mol Cell Neurosci , 30(4): 477–484
doi: 10.1016/j.mcn.2005.08.021 pmid:16209927
159 Millar J K, Pickard B S, Mackie S, James R, Christie S, Buchanan S R, Malloy M P, Chubb J E, Huston E, Baillie G S, Thomson P A, Hill E V, Brandon N J, Rain J C, Camargo L M, Whiting P J, Houslay M D, Blackwood D H, Muir W J, Porteous D J (2005b). DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science , 310(5751): 1187–1191
doi: 10.1126/science.1112915 pmid:16293762
160 Millar J K, Wilson-Annan J C, Anderson S, Christie S, Taylor M S, Semple C A, Devon R S, St Clair D M, Muir W J, Blackwood D H, Porteous D J (2000b). Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet , 9(9): 1415–1423
doi: 10.1093/hmg/9.9.1415 pmid:10814723
161 Miller K E, Sheetz M P (2004). Axonal mitochondrial transport and potential are correlated. J Cell Sci , 117(Pt 13): 2791–2804
doi: 10.1242/jcs.01130 pmid:15150321
162 Miyoshi K, Asanuma M, Miyazaki I, Diaz-Corrales F J, Katayama T, Tohyama M, Ogawa N (2004). DISC1 localizes to the centrosome by binding to kendrin. Biochem Biophys Res Commun , 317(4): 1195–1199
doi: 10.1016/j.bbrc.2004.03.163 pmid:15094396
163 Miyoshi K, Honda A, Baba K, Taniguchi M, Oono K, Fujita T, Kuroda S, Katayama T, Tohyama M (2003). Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol Psychiatry , 8(7): 685–694
doi: 10.1038/ pmid:12874605
164 Moens L N, De Rijk P, Reumers J, Van den Bossche M J, Glassee W, De Zutter S, Lenaerts A S, Nordin A, Nilsson L G, Medina Castello I, Norrback K F, Goossens D, Van Steen K, Adolfsson R, Del-Favero J (2011). Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population. PLoS ONE , 6(8): e23450
doi: 10.1371/journal.pone.0023450 pmid:21853134
165 Morris J A, Kandpal G, Ma L, Austin C P (2003). DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum Mol Genet , 12(13): 1591–1608
doi: 10.1093/hmg/ddg162 pmid:12812986
166 Mouaffak F, Kebir O, Chayet M, Tordjman S, Vacheron M N, Millet B, Jaafari N, Bellon A, Olié J P, Krebs M O (2011). Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia. Pharmacogenomics J , 11(4): 267–273
doi: 10.1038/tpj.2010.40 pmid:20531374
167 Murdoch H, Mackie S, Collins D M, Hill E V, Bolger G B, Klussmann E, Porteous D J, Millar J K, Houslay M D (2007). Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels. J Neurosci , 27(35): 9513–9524
doi: 10.1523/JNEUROSCI.1493-07.2007 pmid:17728464
168 Murdoch H, Vadrevu S, Prinz A, Dunlop A J, Klussmann E, Bolger G B, Norman J C, Houslay M D (2011). Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function. J Cell Sci , 124(Pt 13): 2253–2266
doi: 10.1242/jcs.082982 pmid:21652625
169 Mykytyn K, Braun T, Carmi R, Haider N B, Searby C C, Shastri M, Beck G, Wright A F, Iannaccone A, Elbedour K, Riise R, Baldi A, Raas-Rothschild A, Gorman S W, Duhl D M, Jacobson S G, Casavant T, Stone E M, Sheffield V C (2001). Identification of the gene that, when mutated, causes the human obesity syndrome BBS4. Nat Genet , 28(2): 188–191
doi: 10.1038/88925 pmid:11381270
170 Nagai T, Kitahara Y, Ibi D, Nabeshima T, Sawa A, Yamada K (2011). Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment. Behav Brain Res , 225(1): 305–310
doi: 10.1016/j.bbr.2011.07.049 pmid:21835207
171 Nakata K, Lipska B K, Hyde T M, Ye T, Newburn E N, Morita Y, Vakkalanka R, Barenboim M, Sei Y, Weinberger D R, Kleinman J E (2009). DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms. Proc Natl Acad Sci USA , 106(37): 15873–15878
doi: 10.1073/pnas.0903413106 pmid:19805229
172 Namba T, Ming G L, Song H, Waga C, Enomoto A, Kaibuchi K, Kohsaka S, Uchino S (2011). NMDA receptor regulates migration of newly generated neurons in the adult hippocampus via Disrupted-In-Schizophrenia 1 (DISC1). J Neurochem , 118(1): 34–44
doi: 10.1111/j.1471-4159.2011.07282.x pmid:21517847
173 Narayanan S, Arthanari H, Wolfe M S, Wagner G (2011). Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly. J Biol Chem , 286(51): 44266–44276
doi: 10.1074/jbc.M111.271593 pmid:21998303
174 Nicodemus K K, Callicott J H, Higier R G, Luna A, Nixon D C, Lipska B K, Vakkalanka R, Giegling I, Rujescu D, St Clair D, Muglia P, Shugart Y Y, Weinberger D R (2010). Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging. Hum Genet , 127(4): 441–452
doi: 10.1007/s00439-009-0782-y pmid:20084519
175 Nigg E A, Raff J W (2009). Centrioles, centrosomes, and cilia in health and disease. Cell , 139(4): 663–678
doi: 10.1016/j.cell.2009.10.036 pmid:19914163
176 Niwa M, Kamiya A, Murai R, Kubo K, Gruber A J, Tomita K, Lu L, Tomisato S, Jaaro-Peled H, Seshadri S, Hiyama H, Huang B, Kohda K, Noda Y, O’Donnell P, Nakajima K, Sawa A, Nabeshima T (2010). Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron , 65(4): 480–489
doi: 10.1016/j.neuron.2010.01.019 pmid:20188653
177 Olincy A, House R, Gao B, Recksiek P, Phang T L, Sullivan B, Hollis J P, Hopkins J, Shade T, Edwards M G, Vianzon R, Griffiths C, Ceilley J, Helfrich R W, Ritvo J, Weis E, Weiss D, Gault J (2011). Elevated DISC1 transcript levels in PBMCs during acute psychosis in patients with schizophrenia. Transl Biomed , 2(1): pii183
178 Osbun N, Li J, O’Driscoll M C, Strominger Z, Wakahiro M, Rider E, Bukshpun P, Boland E, Spurrell C H, Schackwitz W, Pennacchio L A, Dobyns W B, Black G C, Sherr E H (2011). Genetic and functional analyses identify DISC1 as a novel callosal agenesis candidate gene. Am J Med Genet A , 155A(8): 1865–1876
doi: 10.1002/ajmg.a.34081 pmid:21739582
179 Ott C, Ross K, Straub S, Thiede B, G?tz M, Goosmann C, Krischke M, Mueller M J, Krohne G, Rudel T, Kozjak-Pavlovic V (2012). Sam50 functions in mitochondrial intermembrane space bridging and biogenesis of respiratory complexes. Mol Cell Biol , 32(6): 1173–1188
doi: 10.1128/MCB.06388-11 pmid:22252321
180 Ottis P, Bader V, Trossbach S V, Kretzschmar H, Michel M, Leliveld S R, Korth C (2011). Convergence of two independent mental disease genes on the protein level: recruitment of dysbindin to cell-invasive disrupted-in-schizophrenia 1 aggresomes. Biol Psychiatry , 70(7): 604–610
doi: 10.1016/j.biopsych.2011.03.027 pmid:21531389
181 Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K, Okawa M, Yamada N, Hatten M E, Snyder S H, Ross C A, Sawa A (2003). Disrupted In Schizophrenia 1 (DISC1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc Natl Acad Sci USA , 100(1): 289–294
doi: 10.1073/pnas.0136913100 pmid:12506198
182 Palo O M, Antila M, Silander K, Hennah W, Kilpinen H, Soronen P, Tuulio-Henriksson A, Kiesepp? T, Partonen T, L?nnqvist J, Peltonen L, Paunio T (2007). Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments. Hum Mol Genet , 16(20): 2517–2528
doi: 10.1093/hmg/ddm207 pmid:17673452
183 Papaleo F, Lipska B K, Weinberger D R (2012). Mouse models of genetic effects on cognition: relevance to schizophrenia. Neuropharmacology , 62(3): 1204–1220
doi: 10.1016/j.neuropharm.2011.04.025 pmid:21557953
184 Park Y U, Jeong J, Lee H, Mun J Y, Kim J H, Lee J S, Nguyen M D, Han S S, Suh P G, Park S K (2010). Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. Proc Natl Acad Sci USA , 107(41): 17785–17790
doi: 10.1073/pnas.1004361107 pmid:20880836
185 Paspalas C D, Wang M, Arnsten A F (2012). Constellation of HCN channels and cAMP regulating proteins in dendritic spines of the primate prefrontal cortex: Potential substrate for working memory deficits in schizophrenia. Cereb Cortex .
doi: 10.1093/cercor/bhs152
186 Paul L K, Brown W S, Adolphs R, Tyszka J M, Richards L J, Mukherjee P, Sherr E H (2007). Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity. Nat Rev Neurosci , 8(4): 287–299
doi: 10.1038/nrn2107 pmid:17375041
187 Pletnikov M V, Ayhan Y, Nikolskaia O, Xu Y, Ovanesov M V, Huang H, Mori S, Moran T H, Ross C A (2008). Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry 13: 173–186, 115
188 Pogorelov V M, Nomura J, Kim J, Kannan G, Ayhan Y, Yang C, Taniguchi Y, Abazyan B, Valentine H, Krasnova I N, Kamiya A, Cadet J L, Wong D F, Pletnikov M V (2012). Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model. Neuropharmacology , 62(3): 1242–1251
doi: 10.1016/j.neuropharm.2011.02.003 pmid:21315744
189 Porteous D (2008). Genetic causality in schizophrenia and bipolar disorder: out with the old and in with the new. Curr Opin Genet Dev , 18(3): 229–234
doi: 10.1016/j.gde.2008.07.005 pmid:18674616
190 Prata D P, Mechelli A, Fu C H, Picchioni M, Kane ., Kalidindi S, Mcdonald C, Kravariti E, Toulopoulou T, Miorelli A, Murray R, Collier D A, Mcguire P K (2008). Effect of disrupted-in-schizophrenia-1 on pre-frontal cortical function. Mol Psychiatry , 13: 915–917, 909
191 Prata D P, Mechelli A, Picchioni M, Fu C H, Kane F, Kalidindi S, McDonald C, Kravariti E, Toulopoulou T, Bramon E, Walshe M, Murray R, Collier D A, McGuire P K (2011). No association of Disrupted-in-Schizophrenia-1 variation with prefrontal function in patients with schizophrenia and bipolar disorder. Genes Brain Behav , 10(3): 276–285
doi: 10.1111/j.1601-183X.2010.00665.x pmid:21091867
192 Puthuran M J, Rowland-Hill C A, Simpson J, Pairaudeau P W, Mabbott J L, Morris S M, Crow Y J (2005). Chromosome 1q42 deletion and agenesis of the corpus callosum. Am J Med Genet A , 138(1): 68–69
doi: 10.1002/ajmg.a.30888 pmid:16097003
193 Ram Murthy A, Purushottam M, Kiran Kumar H B, Vallikiran M, Krishna N, Jayramu Sriharsha K, Janardhan Reddy Y C, Ghosh S, Jain S (2012). Gender-specific association of TSNAX/DISC1 locus for schizophrenia and bipolar affective disorder in South Indian population. J Hum Genet , 57(8): 523–530
194 Ramsey A J, Milenkovic M, Oliveira A F, Escobedo-Lozoya Y, Seshadri S, Salahpour A, Sawa A, Yasuda R, Caron M G (2011). Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. Proc Natl Acad Sci USA , 108(14): 5795–5800
doi: 10.1073/pnas.1012621108 pmid:21436042
195 Rastogi A, Zai C, Likhodi O, Kennedy J L, Wong A H (2009). Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia. Schizophr Res , 114(1–3): 39–49
doi: 10.1016/j.schres.2009.06.019 pmid:19632097
196 Rauch A, Thiel C T, Schindler D, Wick U, Crow Y J, Ekici A B, van Essen A J, Goecke T O, Al-Gazali L, Chrzanowska K H, Zweier C, Brunner H G, Becker K, Curry C J, Dallapiccola B, Devriendt K, D?rfler A, Kinning E, Megarbane A, Meinecke P, Semple R K, Spranger S, Toutain A, Trembath R C, Voss E, Wilson L, Hennekam R, de Zegher F, D?rr H G, Reis A (2008). Mutations in the pericentrin (PCNT) gene cause primordial dwarfism. Science , 319(5864): 816–819
doi: 10.1126/science.1151174 pmid:18174396
197 Raznahan A, Lee Y, Long R, Greenstein D, Clasen L, Addington A, Rapoport J L, Giedd J N (2011). Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents. Mol Psychiatry , 16(9): 917–926
doi: 10.1038/mp.2010.72 pmid:20628343
198 Reiner O, Carrozzo R, Shen Y, Wehnert M, Faustinella F, Dobyns W B, Caskey C T, Ledbetter D H (1993). Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats. Nature , 364(6439): 717–721
doi: 10.1038/364717a0 pmid:8355785
199 Rezin G T, Amboni G, Zugno A I, Quevedo J, Streck E L (2009). Mitochondrial dysfunction and psychiatric disorders. Neurochem Res , 34(6): 1021–1029
doi: 10.1007/s11064-008-9865-8 pmid:18979198
200 Rice G M, Qi Z, Selzer R, Richmond T, Thompson K, Pauli R M, Yu J (2006). Microdissection-based high-resolution genomic array analysis of two patients with cytogenetically identical interstitial deletions of chromosome 1q but distinct clinical phenotypes. Am J Med Genet A , 140(15): 1637–1643
doi: 10.1002/ajmg.a.31349 pmid:16835927
201 Rosenbloom K R, Dreszer T R, Pheasant M, Barber G P, Meyer L R, Pohl A, Raney B J, Wang T, Hinrichs A S, Zweig A S, Fujita P A, Learned K, Rhead B, Smith K E, Kuhn R M, Karolchik D, Haussler D, Kent W J (2010). ENCODE whole-genome data in the UCSC Genome Browser. Nucleic Acids Res , 38(Database issue): D620–D625
doi: 10.1093/nar/gkp961 pmid:19920125
202 Sachs N A, Sawa A, Holmes S E, Ross C A, DeLisi L E, Margolis R L (2005). A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder. Mol Psychiatry , 10(8): 758–764
doi: 10.1038/ pmid:15940305
203 Saetre P, Agartz I, De Franciscis A, Lundmark P, Djurovic S, K?hler A, Andreassen O A, Jakobsen K D, Rasmussen H B, Werge T, Hall H, Terenius L, J?nsson E G (2008). Association between a disrupted-in-schizophrenia 1 (DISC1) single nucleotide polymorphism and schizophrenia in a combined Scandinavian case-control sample. Schizophr Res , 106(2–3): 237–241
doi: 10.1016/j.schres.2008.08.024 pmid:18818052
204 Sasaki S, Shionoya A, Ishida M, Gambello M J, Yingling J, Wynshaw-Boris A, Hirotsune S (2000). A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Neuron , 28(3): 681–696
doi: 10.1016/S0896-6273(00)00146-X pmid:11163259
205 Sawamura N, Ando T, Maruyama Y, Fujimuro M, Mochizuki H, Honjo K, Shimoda M, Toda H, Sawamura-Yamamoto T, Makuch L A, Hayashi A, Ishizuka K, Cascella N G, Kamiya A, Ishida N, Tomoda T, Hai T, Furukubo-Tokunaga K, Sawa A (2008). Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly. Mol Psychiatry , 13: 1138–1148, 1069
206 Sawamura N, Sawamura-Yamamoto T, Ozeki Y, Ross C A, Sawa A (2005). A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. Proc Natl Acad Sci USA , 102(4): 1187–1192
doi: 10.1073/pnas.0406543102 pmid:15657124
207 Schosser A, Gaysina D, Cohen-Woods S, Chow P C, Martucci L, Craddock N, Farmer A, Korszun A, Gunasinghe C, Gray J, Jones L, Tozzi F, Perry J, Muglia P, Owen M J, Craig I W, McGuffin P (2010). Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. Mol Psychiatry , 15(8): 844–849
doi: 10.1038/mp.2009.21 pmid:19255581
208 Schulz P, Steimer T (2009). Neurobiology of circadian systems. CNS Drugs , 23(Suppl 2): 3–13
doi: 10.2165/11318620-000000000-00000 pmid:19708721
209 Schumacher J, Laje G, Abou Jamra R, Becker T, Mühleisen T W, Vasilescu C, Mattheisen M, Herms S, Hoffmann P, Hillmer A M, Georgi A, Herold C, Schulze T G, Propping P, Rietschel M, McMahon F J, N?then M M, Cichon S (2009). The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations. Hum Mol Genet , 18(14): 2719–2727
doi: 10.1093/hmg/ddp204 pmid:19414483
210 Serretti A, Drago A, De Ronchi D (2009). Lithium pharmacodynamics and pharmacogenetics: focus on inositol mono phosphatase (IMPase), inositol poliphosphatase (IPPase) and glycogen sinthase kinase 3 beta (GSK-3 beta). Curr Med Chem , 16(15): 1917–1948
doi: 10.2174/092986709788186101 pmid:19442155
211 Seshadri S, Kamiya A, Yokota Y, Prikulis I, Kano S, Hayashi-Takagi A, Stanco A, Eom T Y, Rao S, Ishizuka K, Wong P, Korth C, Anton E S, Sawa A (2010). Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proc Natl Acad Sci USA , 107(12): 5622–5627
doi: 10.1073/pnas.0909284107 pmid:20212127
212 Shaikh M, Hall M H, Schulze K, Dutt A, Li K, Williams I, Walshe M, Constante M, Broome M, Picchioni M, Toulopoulou T, Collier D, Stahl D, Rijsdijk F, Powell J, Murray R M, Arranz M, Bramon E (2011). Effect of DISC1 on the P300 Waveform in Psychosis. Schizophr Bull ,
doi: 10.1093/schbul/sbr101
213 Shen S, Lang B, Nakamoto C, Zhang F, Pu J, Kuan S L, Chatzi C, He S, Mackie I, Brandon N J, Marquis K L, Day M, Hurko O, McCaig C D, Riedel G, St Clair D (2008). Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. J Neurosci , 28(43): 10893–10904
doi: 10.1523/JNEUROSCI.3299-08.2008 pmid:18945897
214 Shimizu S, Matsuzaki S, Hattori T, Kumamoto N, Miyoshi K, Katayama T, Tohyama M (2008). DISC1-kendrin interaction is involved in centrosomal microtubule network formation. Biochem Biophys Res Commun , 377(4): 1051–1056
doi: 10.1016/j.bbrc.2008.10.100 pmid:18955030
215 Shinoda T, Taya S, Tsuboi D, Hikita T, Matsuzawa R, Kuroda S, Iwamatsu A, Kaibuchi K (2007). DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2. J Neurosci , 27(1): 4–14
doi: 10.1523/JNEUROSCI.3825-06.2007 pmid:17202467
216 Shoji H, Toyama K, Takamiya Y, Wakana S, Gondo Y, Miyakawa T (2012). Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and-L100P mutant mice. BMC Res Notes , 5(1): 108
doi: 10.1186/1756-0500-5-108 pmid:22348257
217 Singh K K, De Rienzo G, Drane L, Mao Y, Flood Z, Madison J, Ferreira M, Bergen S, King C, Sklar P, Sive H, Tsai L H (2011). Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development. Neuron , 72(4): 545–558
doi: 10.1016/j.neuron.2011.09.030 pmid:22099458
218 Singh K K, Ge X, Mao Y, Drane L, Meletis K, Samuels B A, Tsai L H (2010). Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron , 67(1): 33–48
doi: 10.1016/j.neuron.2010.06.002 pmid:20624590
219 Siuciak J A, Chapin D S, McCarthy S A, Martin A N (2007). Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme. Psychopharmacology (Berl) , 192(3): 415–424
doi: 10.1007/s00213-007-0727-x pmid:17333137
220 Soares D C, Carlyle B C, Bradshaw N J, Porteous D J (2011). DISC1: structure, function, and therapeutic potential for major mental illness. ACS Chem Neurosci , 2(11): 609–632
doi: 10.1021/cn200062k pmid:22116789
221 Song W, Li W, Feng J, Heston L L, Scaringe W A, Sommer S S (2008). Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia. Biochem Biophys Res Commun , 367(3): 700–706
doi: 10.1016/j.bbrc.2007.12.117 pmid:18164685
222 Song W, Li W, Noltner K, Yan J, Green E, Grozeva D, Jones I R, Craddock N, Longmate J, Feng J, Sommer S S (2010). Identification of high risk DISC1 protein structural variants in patients with bipolar spectrum disorder. Neurosci Lett , 486(3): 136–140
doi: 10.1016/j.neulet.2010.09.027 pmid:20850505
223 Spiteri E, Konopka G, Coppola G, Bomar J, Oldham M, Ou J, Vernes S C, Fisher S E, Ren B, Geschwind D H (2007). Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. Am J Hum Genet , 81(6): 1144–1157
doi: 10.1086/522237 pmid:17999357
224 Sprooten E, Sussmann J E, Moorhead T W, Whalley H C, Ffrench-Constant C, Blumberg H P, Bastin M E, Hall J, Lawrie S M, McIntosh A M (2011). Association of white matter integrity with genetic variation in an exonic DISC1 SNP. Mol Psychiatry , 16(7): 685, 688–689
doi: 10.1038/mp.2011.69 pmid:21358711
225 Steinecke A, Gampe C, Valkova C, Kaether C, Bolz J (2012). Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons. J Neurosci , 32(2): 738–745
doi: 10.1523/JNEUROSCI.5036-11.2012 pmid:22238109
226 Stuhlmiller T J, Garcia-Castro M I (2012). Current perspectives of the signaling pathways directing neural crest induction. Cell Mol Life Sci , 69(22): 3715–3737
227 Sullivan P F, Daly M J, O’Donovan M (2012). Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet , 13(8): 537–551
doi: 10.1038/nrg3240 pmid:22777127
228 Szeszko P R, Hodgkinson C A, Robinson D G, Derosse P, Bilder R M, Lencz T, Burdick K E, Napolitano B, Betensky J D, Kane J M, Goldman D, Malhotra A K (2008). DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia. Biol Psychol , 79(1): 103–110
doi: 10.1016/j.biopsycho.2007.10.011 pmid:18078707
229 Takahashi T, Suzuki M, Tsunoda M, Maeno N, Kawasaki Y, Zhou S Y, Hagino H, Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N (2009). The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia. Psychiatry Res , 172(2): 128–135
doi: 10.1016/j.pscychresns.2009.01.005 pmid:19304459
230 Taya S, Shinoda T, Tsuboi D, Asaki J, Nagai K, Hikita T, Kuroda S, Kuroda K, Shimizu M, Hirotsune S, Iwamatsu A, Kaibuchi K (2007). DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. J Neurosci , 27(1): 15–26
doi: 10.1523/JNEUROSCI.3826-06.2006 pmid:17202468
231 Taylor M S, Devon R S, Millar J K, Porteous D J (2003). Evolutionary constraints on the Disrupted in Schizophrenia locus. Genomics , 81(1): 67–77
doi: 10.1016/S0888-7543(02)00026-5 pmid:12573262
232 Thomson P A, Harris S E, Starr J M, Whalley L J, Porteous D J, Deary I J (2005). Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. Neurosci Lett , 389(1): 41–45
doi: 10.1016/j.neulet.2005.07.004 pmid:16054297
233 Thomson P A, Macintyre D J, Hamilton G, Dominiczak A, Smith B H, Morris A, Evans K L, Porteous D J (2012). Association of DISC1 variants with age of onset in a population-based sample of recurrent major depression. Mol Psychiatry ,
doi: 10.1038/mp.2012.117
234 Tiwary B K (2012). The severity of mental disorders is linked to interaction among candidate genes. Integr Biol (Camb) , 4(9): 1096–1101
doi: 10.1039/c2ib20066j pmid:22777684
235 Toda H, Mochizuki H, Flores R 3rd, Josowitz R, Krasieva T B, Lamorte V J, Suzuki E, Gindhart J G, Furukubo-Tokunaga K, Tomoda T (2008). UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly. Genes Dev , 22(23): 3292–3307
doi: 10.1101/gad.1734608 pmid:19056884
236 Tomita K, Kubo K, Ishii K, Nakajima K (2011). Disrupted-in-Schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development. Hum Mol Genet , 20(14): 2834–2845
doi: 10.1093/hmg/ddr194 pmid:21540240
237 Trinh M A, Kaphzan H, Wek R C, Pierre P, Cavener D R, Klann E (2012). Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. Cell Rep , 1(6): 676–688
doi: 10.1016/j.celrep.2012.04.010 pmid:22813743
238 Ushijima K, Koyanagi S, Sato Y, Ogata T, Matsunaga N, Fujimura A, Ohdo S (2012). Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain. Mol Pharmacol , 82(2): 264–270
doi: 10.1124/mol.112.079079 pmid:22572884
239 Valiente M, Martini F J (2009). Migration of cortical interneurons relies on branched leading process dynamics. Cell Adhes Migr , 3(3): 278–280
doi: 10.4161/cam.3.3.8832 pmid:19535916
240 van Os J, Rutten B P, Poulton R (2008). Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophr Bull , 34(6): 1066–1082
doi: 10.1093/schbul/sbn117 pmid:18791076
241 Vernes S C, Nicod J, Elahi F M, Coventry J A, Kenny N, Coupe A M, Bird L E, Davies K E, Fisher S E (2006). Functional genetic analysis of mutations implicated in a human speech and language disorder. Hum Mol Genet , 15(21): 3154–3167
doi: 10.1093/hmg/ddl392 pmid:16984964
242 Walker R M, Hill A E, Newman A C, Hamilton G, Torrance H S, Anderson S M, Ogawa F, Derizioti P, Nicod J, Vernes S C, Fisher S E, Thomson P A, Porteous D J, Evans K L (2012). The DISC1 promoter: characterization and regulation by FOXP2. Hum Mol Genet , 21(13): 2862–2872
doi: 10.1093/hmg/dds111 pmid:22434823
243 Wang Q, Charych E I, Pulito V L, Lee J B, Graziane N M, Crozier R A, Revilla-Sanchez R, Kelly M P, Dunlop A J, Murdoch H, Taylor N, Xie Y, Pausch M, Hayashi-Takagi A, Ishizuka K, Seshadri S, Bates B, Kariya K, Sawa A, Weinberg R J, Moss S J, Houslay M D, Yan Z, Brandon N J (2011a). The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Mol Psychiatry , 16(10): 1006–1023
doi: 10.1038/mp.2010.87 pmid:20838393
244 Wang Y, Kaneko N, Asai N, Enomoto A, Isotani-Sakakibara M, Kato T, Asai M, Murakumo Y, Ota H, Hikita T, Namba T, Kuroda K, Kaibuchi K, Ming G L, Song H, Sawamoto K, Takahashi M (2011b). Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain. J Neurosci , 31(22): 8109–8122
doi: 10.1523/JNEUROSCI.1130-11.2011 pmid:21632933
245 Watatani Y, Ichikawa K, Nakanishi N, Fujimoto M, Takeda H, Kimura N, Hirose H, Takahashi S, Takahashi Y (2008). Stress-induced translation of ATF5 mRNA is regulated by the 5′-untranslated region. J Biol Chem , 283(5): 2543–2553
doi: 10.1074/jbc.M707781200 pmid:18055463
246 Wei Q, Diao F, Kang Z, Gan Z, Han Z, Zheng L, Li L, Guo X, Shan B, Liu C, Zhao J, Zhang J (2012). The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population. Neurosci Lett , 517(1): 21–24
doi: 10.1016/j.neulet.2012.03.098 pmid:22516458
247 Whalley H C, Sussmann J E, Johnstone M, Romaniuk L, Redpath H, Chakirova G, Mukherjee P, Hall J, Johnstone E C, Lawrie S M, McIntosh A M (2012). Effects of a mis-sense DISC1 variant on brain activation in two cohorts at high risk of bipolar disorder or schizophrenia. Am J Med Genet B Neuropsychiatr Genet , 159B(3): 343–353
doi: 10.1002/ajmg.b.32035 pmid:22337479
248 Williams J M, Beck T F, Pearson D M, Proud M B, Cheung S W, Scott D A (2009). A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder. Am J Med Genet A , 149A(8): 1758–1762
doi: 10.1002/ajmg.a.32941 pmid:19606485
249 Wood J D, Bonath F, Kumar S, Ross C A, Cunliffe V T (2009). Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain. Hum Mol Genet , 18(3): 391–404
doi: 10.1093/hmg/ddn361 pmid:18996920
250 Wu D, Pan W (2010). GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci , 35(3): 161–168
doi: 10.1016/j.tibs.2009.10.002 pmid:19884009
251 Wulff K, Dijk D J, Middleton B, Foster R G, Joyce E M (2012). Sleep and circadian rhythm disruption in schizophrenia. Br J Psychiatry , 200(4): 308–316
doi: 10.1192/bjp.bp.111.096321 pmid:22194182
252 Wulff K, Porcheret K, Cussans E, Foster R G (2009). Sleep and circadian rhythm disturbances: multiple genes and multiple phenotypes. Curr Opin Genet Dev , 19(3): 237–246
doi: 10.1016/j.gde.2009.03.007 pmid:19423332
253 Wynshaw-Boris A (2007). Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development. Clin Genet , 72(4): 296–304
doi: 10.1111/j.1399-0004.2007.00888.x pmid:17850624
254 Wynshaw-Boris A, Gambello M J (2001). LIS1 and dynein motor function in neuronal migration and development. Genes Dev , 15(6): 639–651
doi: 10.1101/gad.886801 pmid:11274050
255 Yi M, Weaver D, Hajnóczky G (2004). Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit. J Cell Biol , 167(4): 661–672
doi: 10.1083/jcb.200406038 pmid:15545319
256 Yingling J, Youn Y H, Darling D, Toyo-Oka K, Pramparo T, Hirotsune S, Wynshaw-Boris A (2008). Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. Cell , 132(3): 474–486
doi: 10.1016/j.cell.2008.01.026 pmid:18267077
257 Young-Pearse T L, Bai J, Chang R, Zheng J B, LoTurco J J, Selkoe D J (2007). A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. J Neurosci , 27(52): 14459–14469
doi: 10.1523/JNEUROSCI.4701-07.2007 pmid:18160654
258 Young-Pearse T L, Suth S, Luth E S, Sawa A, Selkoe D J (2010). Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. J Neurosci , 30(31): 10431–10440
doi: 10.1523/JNEUROSCI.1445-10.2010 pmid:20685985
259 Zheng F, Wang L, Jia M, Yue W, Ruan Y, Lu T, Liu J, Li J, Zhang D (2011). Evidence for association between Disrupted-in-Schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based association study. Behav Brain Funct , 7(1): 14
doi: 10.1186/1744-9081-7-14 pmid:21569632
260 Zhou D, Palam L R, Jiang L, Narasimhan J, Staschke K A, Wek R C (2008a). Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions. J Biol Chem , 283(11): 7064–7073
doi: 10.1074/jbc.M708530200 pmid:18195013
261 Zhou X, Chen Q, Schaukowitch K, Kelsoe J R, Geyer M A (2010). Insoluble DISC1-Boymaw fusion proteins generated by DISC1 translocation. Mol Psychiatry , 15(7): 669–672
doi: 10.1038/mp.2010.77 pmid:20351725
262 Zhou X, Geyer M A, Kelsoe J R (2008b). Does disrupted-in-schizophrenia (DISC1) generate fusion transcripts? Mol Psychiatry , 13(4): 361–363
doi: 10.1038/ pmid:18347596
263 Zimmerman J E, Naidoo N, Raizen D M, Pack A I (2008). Conservation of sleep: insights from non-mammalian model systems. Trends Neurosci , 31(7): 371–376
doi: 10.1016/j.tins.2008.05.001 pmid:18538867
264 Zuk O, Hechter E, Sunyaev S R, Lander E S (2012). The mystery of missing heritability: Genetic interactions create phantom heritability. Proc Natl Acad Sci USA , 109(4): 1193–1198
doi: 10.1073/pnas.1119675109 pmid:22223662
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