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Frontiers in Biology

Front Biol    2012, Vol. 7 Issue (1) : 24-29
BMP signaling pathway and spinal cord development
Zhihui XIE, Nengyin SHENG, Naihe JING()
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
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The development of spinal cord is a precisely and sequentially regulated process, which is controlled by signaling pathways and transcription factors in each stage. Overwhelming data have shown the essential roles of BMP signaling in different stages of this developmental process. It is also clear that the proper functions of BMP signaling require its cross-talk with several other signaling pathways including Notch, Wnt and retinoic acid (RA) pathways. Here, we highlight the recent advancement in understanding the roles of BMP signaling during neurogenesis, neural tube patterning, axon development and glial differentiation in the spinal cord, and emphasize its integrations with other pathways during these processes.

Keywords BMP      spinal cord      neurogenesis      patterning      glia     
Corresponding Author(s): JING Naihe,   
Issue Date: 01 February 2012
 Cite this article:   
Zhihui XIE,Nengyin SHENG,Naihe JING. BMP signaling pathway and spinal cord development[J]. Front Biol, 2012, 7(1): 24-29.
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Articles by authors
Zhihui XIE
Nengyin SHENG
Naihe JING
Dorsal layerHD factors
dI1Lhx2/9, BarH1, Brn3a
dI2Lhx1/5, Brn3a, Foxd3
dI3Isl1/2, Brn3a, Rnx
dI4Lbx1, Lhx1/5, Pax2
dI5Lbx1, Brn3a, Lmx1b, Rnx/Tlx1
dI6Lbx1, Lhx1/5, Pax2
Tab.1  Determination of spinal cord dorsal layers by homeodomain transcription factors
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