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Frontiers in Biology

Front Biol    2011, Vol. 6 Issue (5) : 351-356
MicroRNAs and drug modulation in cancer: an intertwined new story
Francesca FANINI1, Ivan VANNINI1, Muller FABBRI1,2()
1. Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, 47014, Italy; 2. Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.
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MicroRNAs (miRNAs) are endogenous small non-coding RNAs (ncRNAs) which play important regulatory roles in physiological processes such as cellular differentiation, proliferation, development, apoptosis and stem cell self-renewal. An increasing number of papers have clearly claimed their involvement in cancer, providing, in some cases, also the molecular mechanisms implicated. Several studies led to the conclusion that miRNAs can be effectively used as anticancer agents alone or in combination with existing anticancer drugs. In particular, miRNAs can be effectively used to overcome drug resistance, one of the main factors responsible for anticancer treatment insuccess. One of the main questions remains how to modulate the expression of miRNAs in cancer cells. Interestingly, a few studies have shown that the expression of miRNAs is affected by drugs (including some drugs currently used as anticancer agents), therefore providing the rationale for an intertwined scenario in which miRNAs can be modulated by drugs and, in turn, can affect drug sensitivity of cancer cells.

Keywords miRNAs      cancer      multidrug resistance      transcription factor      chemotherapy     
Corresponding Author(s): FABBRI Muller,   
Issue Date: 01 October 2011
 Cite this article:   
Francesca FANINI,Ivan VANNINI,Muller FABBRI. MicroRNAs and drug modulation in cancer: an intertwined new story[J]. Front Biol, 2011, 6(5): 351-356.
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Articles by authors
Francesca FANINI
miRNAUp/downregulationCorrelation with sensitivity to chemotherapyChemotherapeutic agentTuomor typeAuthor
miR-125bAnthracyclineBreastCliment et al., 2007
miR-451DoxorubicinBreastKovalchuk et al., 2008
miR-221Endocrine therapyBreastMiller et al., 2008
miR-let7iFulvestrantBreastXin et al., 2009
miR-15bVincristine adriamycinGastricXia et al., 2008
5-fluoruracil cisplatin
mitomycin C
miR-30cPaclitaxelOvarianSorrentino et al., 2008
miR-214CisplatinOvarianYang et al., 2008
let-7 cluster
miR-221Tumor necrosis factor-related apoptosis-inducing ligandNSCLCGarofalo et al., 2008
miR-34aCamptotechinProstateFujita et al., 2008
Tab.1  miRNAs involved in multidrug resistance
MoleculeTargetUp/DownregulationChemotherapeutic agent in combinationTuomor typeAuthor
CurcuminmiR-21GemcitabinePancreasAli et al., 2010
CDF synthetic analogue
CurcuminmiR-200bGemcitabinePancreasAli et al., 2010
CDF synthetic analogmiR-200c
EstrogenmiR-17-92BreastCastellano et al., 2009
EstrogenmiR-128aLetrozoleBreastMasri et al., 2010
p53 mutatedmiR-34 familyOvarianCorney et al., 2007
p53 wild typemiR-192OvarianGeorges et al., 2008
Tab.2  miRNAs modulators
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