The high-end equipment intelligent manufacturing (HEIM) industry is of strategic importance to national and economic security. Engineering management (EM) for HEIM is a complex, innovative process that integrates natural science, technology, management science, social science, and the human spirit. New-generation information technology (IT), including the internet, cloud computing, big data, and artificial intelligence, have made a remarkable influence on HEIM and its engineering management activities, such as product system construction, product life cycle management, manufacturing resources organization, manufacturing model innovation, and reconstruction of the enterprise ecosystem. Engineering management for HEIM is a key topic at the frontier of international academic research. This study systematically reviews the current research on issues pertaining to engineering management for HEIM under the new-generation IT environment. These issues include cross-life cycle management, network collaboration management, task integration management of innovative development, operation optimization of smart factories, quality and reliability management, information management, and intelligent decision making. The challenges presented by these issues and potential research opportunities are also summarized and discussed.