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| Base editing technology |
Yidi SUN1,2, Erwei ZUO3, Hui YANG4( ) |
1. Key Laboratory of Systems Biology, Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China
2. Bio-Med Big Data Center, Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai 200031, China
3. Shenzhen Branch, Guangdong Labratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China
4. Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China |
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| 10 |
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| 11 |
S Jin, Y Zong, Q Gao, Z Zhu, Y Wang, P Qin, C Liang, D Wang, J L Qiu, F Zhang, C Gao. Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice. Science, 2019, 364(6437): 292–295
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| 12 |
E Zuo, Y Sun, W Wei, T Yuan, W Ying, H Sun, L Yuan, L M Steinmetz, Y Li, H Yang. Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos. Science, 2019, 364(6437): 289–292
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| 13 |
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| 14 |
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pmid: 31181567
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